Angpt2
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Official Full Name
angiopoietin 2
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Overview
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chromatography Reagents
- Protein Pre-coupled Magnetic Beads
- Canine
- Cattle
- Chicken
- Cynomolgus
- Cynomolgus, Rhesus
- Cynomolgus/Rhesus
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- C
- 6×His
- His
- Fc
- Flag
- FLAG
- GST
- hFc
- Avi
- His (Fc)
- His|T7
- MlgG2a Fc
- MYC
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- Angpt2 Related Articles
- Angpt2 Related Research Area
Angpt2 involved in several pathways and played different roles in them. We selected most pathways Angpt2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Angpt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | PLCE1;PDGFC;Fasl;RGL1;AKT2;PLA2G12A;FGF3;RASGRF2;RASGRP3 |
Rap signaling pathway | FGF5;HRAS;PRKCA;Adcy4;GNAI1;FGFR3;RAP1A;Kitl;PRKCB |
HIF- signaling pathway | PDHA2;PLCG1;BCL2;ENO2;MKNK1;HK2;HIF1A;EIF4E2;PIK3CG |
PIK-Akt signaling pathway | LAMB4;PPP2R5C;TSC1;PIK3CG;FGF3;TCL1A;YWHAB;PTEN;IL3 |
Angpt2 has several biochemical functions, for example, metal ion binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Angpt2 itself. We selected most functions Angpt2 had, and list some proteins which have the same functions with Angpt2. You can find most of the proteins on our site.
Function | Related Protein |
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metal ion binding | KLK1B3;FTR54;NTHL1;NOB1;RIMKLA;ADIPOR2;NQO2;TKT;KLF6 |
protein binding | TYK2;MUC7;PPP1R37;THSD4;CCDC47;EEF1E1;TAOK3;PCP4;TRAF3IP3 |
receptor binding | WNT4B;CD86;SLC9A3R1;RASA1;PVRL1A;IL29;PLA2G1B;HAMP;FKBP1B |
receptor tyrosine kinase binding | ANGPT1;SHC4;SOCS5;SHC3;PCNA;PTPN1;HYAL2;ZFP259;PLCG1 |
Angpt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Angpt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Angpt2.
daap-5; TEK; daap-4; VEGFA; ANXA7; CDKN1A; CSNK2B; IQCB1
- Q&As
- Reviews
Q&As (15)
Ask a questionLike any other therapeutic agent, ANGPT2 inhibitors may have side effects and risks. Common side effects reported in clinical trials include fatigue, headache, gastrointestinal disturbances, and hypertension. However, the specific side effects and risks may vary depending on the individual drug and its mechanism of action. It is important to consult with healthcare professionals and closely monitor patients during treatment to manage any potential adverse effects.
Yes, ANGPT2 inhibitors can be used in combination with other therapies. Combining ANGPT2 inhibitors with other anti-angiogenic agents, chemotherapy, or immunotherapy may have synergistic effects and enhance treatment outcomes. Additionally, they may be combined with conventional treatments in diseases where ANGPT2 is implicated in disease progression or resistance to therapy. Clinical trials are ongoing to evaluate the safety and efficacy of these combination therapies.
Several compounds have been identified as inhibitors of ANGPT2. These include antibodies that specifically target ANGPT2, as well as small molecule inhibitors that interfere with its activity. In contrast, there are no known activators of ANGPT2 identified to date.
Some studies suggest that certain natural compounds or dietary factors can modulate ANGPT2 levels. For example, green tea catechins, resveratrol, and curcumin have demonstrated potential in reducing ANGPT2 expression or activity in preclinical studies. However, more research is needed to determine their efficacy and safety in clinical settings.
Yes, ANGPT2 expression is regulated by various genetic and epigenetic factors. Single nucleotide polymorphisms (SNPs) in the ANGPT2 gene have been associated with altered ANGPT2 expression levels and susceptibility to certain diseases. Additionally, epigenetic modifications, such as DNA methylation and histone modifications, can also regulate ANGPT2 expression by influencing the accessibility of the gene for transcription.
One of the challenges in the development and use of ANGPT2 inhibitors is identifying the patient populations that would benefit most from this therapy. Understanding the precise mechanisms of ANGPT2 in different diseases and identifying reliable biomarkers for patient selection are important areas of future research.
ANGPT2 inhibitors have shown promise in various therapeutic applications. In cancer, blocking ANGPT2 can help normalize tumor blood vessels, improve drug delivery to the tumor, and enhance the effectiveness of anti-cancer therapies. Additionally, ANGPT2 inhibitors may also have potential in the treatment of other diseases involving abnormal angiogenesis, such as age-related macular degeneration, diabetic retinopathy, and inflammatory disorders.
In cancer, ANGPT2 is often upregulated and contributes to tumor angiogenesis and progression. It promotes vessel destabilization, allowing for the formation of leaky and irregular blood vessels within tumors. This abnormal vasculature can support tumor growth, metastasis, and resistance to therapies.
Yes, there are ongoing clinical trials investigating the therapeutic potential of targeting ANGPT2 in cancer and other diseases. These trials evaluate the efficacy and safety of ANGPT2 inhibitors either alone or in combination with other treatments. These studies aim to elucidate whether blocking ANGPT2 can have clinical benefits, such as inhibiting tumor growth, improving patient outcomes, or overcoming therapy resistance.
ANGPT2 has been explored as a potential biomarker in various diseases, including cancer, cardiovascular diseases, and sepsis. Elevated levels of ANGPT2 have been associated with disease progression and poor prognosis in some cases. However, further research is still needed to establish its clinical utility as a diagnostic or prognostic biomarker.
ANGPT2 plays a role in inflammation and immune responses by promoting vascular leakiness and enhancing the recruitment of immune cells to the site of inflammation. It is produced by immune cells, such as macrophages and neutrophils, in response to inflammatory stimuli. ANGPT2 can disrupt endothelial integrity, facilitating the extravasation of immune cells and contributing to the inflammatory process.
Yes, some therapeutic strategies aim to restore the balance between ANGPT1 and ANGPT2. These strategies include the administration of exogenous ANGPT1 or ANGPT2 inhibitors to regulate angiogenesis and vascular stability. The goal is to promote a more balanced and controlled angiogenic response, which may have therapeutic benefits in various diseases characterized by aberrant angiogenesis.
Yes, there are several ongoing clinical trials investigating the use of ANGPT2 inhibitors in various diseases. These trials assess the safety, efficacy, and optimal dosing of ANGPT2 inhibitors either as monotherapy or in combination with other treatments. Some of the diseases being studied include solid tumors, diabetic macular edema, acute myeloid leukemia, and idiopathic pulmonary fibrosis, among others. These trials aim to determine the potential of ANGPT2 inhibitors as a therapeutic option in these diseases.
ANGPT2 inhibitors function as anti-angiogenic agents by blocking the activation of ANGPT2 and its interaction with the Tie2 receptor. Compared to other anti-angiogenic therapies, such as VEGF inhibitors, ANGPT2 inhibitors target a different pathway involved in angiogenesis regulation.
ANGPT2 is produced by various cell types, including endothelial cells, immune cells, and certain cancer cells. Its production can be induced by different stimuli, such as hypoxia, inflammation, and growth factors.
Customer Reviews (5)
Write a reviewThe ANGPT2 protein offers exceptional quality that meets the rigorous demands of experimental research.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the ANGPT2 protein is an invaluable tool for researchers.
What sets the ANGPT2 protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.
the ANGPT2 protein's versatility extends beyond its proven usefulness in in vitro experiments.
Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.
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