SMARCA4
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Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
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Overview
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] -
Synonyms
SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; BRG1; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; transcription activator BRG1; SNF2-beta; SNF2-like 4; protein BRG-1; nuclear protein GRB1; brahma protein-like 1; BRM/SWI2-related gene 1; homeotic gene regulator; protein brahma homolog 1; BRG1-associated factor 190A; sucrose nonfermenting-like 4; ATP-dependent helicase SMARCA4; mitotic growth and transcription activator; global transcription activator homologous sequence;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Insect Cell
- Insect cells
- Insect Cells
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- Sf9 Insect Cell
- Yeast
- C
- His,C
- Flag
- FLAG
- GST
- His
- His (Fc)
- Avi
- His|Flag
- N/A
- N
- MBP
- Involved Pathway
- Protein Function
- Interacting Protein
- SMARCA4 Related Research Area
SMARCA4 involved in several pathways and played different roles in them. We selected most pathways SMARCA4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | KDM4D;ARID1A;ELP2;ARID2;NCOA2;KDM3B;KANSL3;KAT7;SAP18 |
| Chromatin organization | KDM6AL;EED;KANSL3;JHDM1D;KDM4B;YEATS4;KDM1B;GATAD2A;PHF20B |
| Direct p53 effectors | SCN3B;BCL2L14;GDF15;CCNK;AIFM2;S100A2;DDX5;PCBP4;TADA2B |
| Formation of the beta-catenin:TCF transactivating complex | TLE1;H3F3B.1;LEO1;TLE2;ASH2L;PYGO2;TLE3B;H3F3D;SMARCA4 |
| Glucocorticoid receptor regulatory network | SMARCA4;KRT14;KRT5;SMARCD1;BGLAP;POU2F1;NR1I3;SMARCC2;KRT17 |
| Integrated Breast Cancer Pathway | LGALS13;USP15;MYT1;USP38;JAKMIP1;USP16;DCAKD;GDI1;SMARCA4 |
| Prostate Cancer | EP300;HSP90B1;NKX3;CCNE2;TGFA;MAP2K1;SOS1;PIK3R2;INSRR |
| RMTs methylate histone arginines | ARID1A;SMARCE1;ARID2;PRMT5;COPRS;PRMT6;SMARCB1B;SMARCB1;SMARCB1A |
SMARCA4 has several biochemical functions, for example, ATP binding, DNA polymerase binding, DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCA4 itself. We selected most functions SMARCA4 had, and list some proteins which have the same functions with SMARCA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CAMKV;HSP90B1;ZNF143B;CKM;EPHB2B;MYO6A;ABCG4B;TAOK3;PPIP5K1 |
| DNA polymerase binding | ACD;RAD51;PCNA;CDK2AP1;FANCD2;LONP1;HMGB1;SMARCA4;FANCI |
| DNA-dependent ATPase activity | MSH4;RAD51D;ERCC2;RAD51B;DMC1;TTF2;MSH2;MSH3;RAD51C |
| RNA polymerase I CORE element sequence-specific DNA binding | SMARCA4;BAZ2A;TAF1B;PIH1D1;TAF1C;RRN3;SMARCB1;EFCAB11 |
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | ACTL6A;RBBP4;MBD3;SMARCB1;ACTB;GATAD2B;SMARCE1;SMARCC1;HDAC1 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | HDAC2;SMARCA4;HDAC1;SMARCB1;MTA2;RBBP4;CHD4;GATAD2B;ACTB |
| RNA polymerase II transcription coactivator activity | CITED4;CITED1;SOX12;HYAL2;SMARCA4;ISL1;ANKRD1;TBX20;PITX2 |
| Tat protein binding | SMARCA4;MDFIC;NPM1;SMARCB1;GABARAPL1;TRIM32;ACTB;DLL1 |
| androgen receptor binding | Ar;DDX5;RNF14;WIPI1;RNF6;PRPF6;RAN;PIAS1;PARK7 |
| helicase activity | RAD54L;PIF1;GTF2F2B;ACTG2;DHX34;DDX19;EIF4A1;ATRX;DHX58 |
| lysine-acetylated histone binding | BRD9;ATAD2B;CARM1;TAF1;TAF1L;BRD2;PHIP;MLL1;PSME4 |
| contributes_to nucleosomal DNA binding | ACTB;SMARCE1;GATAD2B;MTA2;CHD4;SMARCC1;RBBP4;MBD3;ACTL6A |
| p53 binding | HSPD1;MAPKAPK5;AAAS;ZNF385A;TAF1;DAXX;SMARCA4;PLK3;BRD4 |
| protein N-terminus binding | SLA2;SDCBP;ERCC3;EXOC5;PHB2;MEN1;RPA3;TAF11;EIF3E |
| protein binding | CPS1;TAF9;SLC1A1;C12orf50;PCMT1;CYFIP2;ERCC6L;LCAT;FKBP5 |
| transcription coactivator activity | TRIP4;Ankar;ECD;MTDH;COPS5;BCL10;HTATIP2;LPIN3;NRIP1 |
| transcription corepressor activity | SKOR1;TMEM38A;DDX54;MXD4;CITED2;DAXX;UBP1;MNT;AEBP2 |
| transcription factor binding | GPX3;MAPK9;SOX8;LEF1;HES4;RBPJ;HDAC9;IFI203;PPID |
SMARCA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCA4.
ARID1A
- Q&As
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Q&As (5)
Ask a questionEpigenetic therapies that modulate gene expression could indirectly affect SMARCA4-altered cancers, though specific targeting remains a challenge.
Yes, there are genetic tests available to identify SMARCA4 mutations in tumors, aiding in prognosis and treatment decisions.
Yes, there are clinical trials exploring new treatment strategies for SMARCA4-altered cancers, aiming to improve patient outcomes.
No, SMARCA4's functions extend beyond cancer and have implications in various biological processes, including development and differentiation.
Patients with SMARCA4 mutations in their tumors often face a poorer prognosis, which necessitates tailored treatment approaches.
Customer Reviews (3)
Write a reviewThe SMARCA4 protein offers exceptional quality that meets the rigorous demands of experimental research.
It exhibits exceptional performance in ELISA assays, making it an excellent choice for researchers studying angiopoietins, angiogenesis, or vascular biology.
Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.
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