ITGB1
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Official Full Name
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
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Overview
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. -
Synonyms
CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; integrin beta-1 (avian); ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12);
- Recombinant Proteins
- Cell & Tissue Lysates
- Others
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Camelus bactrianus (Bactrian camel)
- Chicken
- Felis catus (Cat) (Felis silvestris catus)
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Pig
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human
- Human Cell
- Human cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- His|Avi
- His|GST
- His|SUMO
- His|T7
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ITGB1 involved in several pathways and played different roles in them. We selected most pathways ITGB1 participated on our site, such as Rap signaling pathway, Phagosome, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | PIK3R2;PARD6B;SKAP1;TLN1;PRKD2;FGF2;CALM1;FYB;CALML5 |
| Phagosome | FCGR1A;cgr2b;SEC61AL2;HLA-E;ATP6V0A1A;CD209;FCGR3B;RAC1A;CTSSA |
| PIK-Akt signaling pathway | PDGFB;GYS2;IRS1;GNGT2;MAPK1;FGF22;MCL1;ITGA3;GSK3B |
| Axon guidance | Sema3f;LIMK1;CAP2;ARPC2;PPP3CA;SCN3B;SEMA4B;CLTB;CNKSR1 |
| Focal adhesion | MYLK4;THBS1;MYL2;FYNA;RAC1B;TNK1;RAP1AA;PIP5K1C;ITGB1 |
| ECM-receptor interaction | ITGA11A;ITGA10;COL6A2;SDC1;ITGB6;LAMB2;COL6A6;FN1A;ITGA5 |
| Cell adhesion molecules (CAMs) | BF1;PECAM1;NRXN2A;Itgam&Itgb2;CD28;PDCD1;CD80;Icosl;CNTN2 |
| Platelet activation | RAP1B;GUCY1A3;MAPK13;PLCB2;APBB1IP;PIK3CG;PLCB3;PPP1R12A;PLCB4 |
| Leukocyte transendothelial migration | CDC42;CLDN16;PIK3CG;CLDN23;MYL2;CLDN2;CXCR4;MAPK12;ACTN3 |
| Regulation of actin cytoskeleton | EGFRA;ARPC5L;TMSB4X;F2;FGF6A;SCINLA;FGFR3;ITGA9;BDKRB2 |
| Bacterial invasion of epithelial cells | CAV3;FN1;ELMO2;CBLC;SEPT1;PIK3CB;CBL;CBLB;PIK3R1 |
| Pathogenic Escherichia coli infection | CDC42;TUBA3C;KRT18;WASL;YWHAZ;RHOA;OCLN;ACTG1;ROCK2 |
| Shigellosis | UBE2D2;FBXW11;ELMO3;ITGB1;MAPK12;RHOG;ACTG1;U2AF1;VCL |
| Pertussis | GNAI2;IL12B;MAPK13;IL-8;LY96;C4BPA;CASP7;CASP1;ITGAM |
| Leishmaniasis | NFKBIB;FCGR4;CYBA;HLA-DQB1;ITGA4;MYD88;HLA-DRA;HLA-DOB;IL1A |
| Toxoplasmosis | MAP2K6;HLA-DMA;TNFRSF1A;LY96;HLA-DQB1;IRGM1;BIRC3;PDPK1;TGFB1 |
| Pathways in cancer | PAX8;LPAR6;Shh;LAMB4;FGF21;AGTR1B;CBL;STAT3;NCOA4 |
| Proteoglycans in cancer | Fzd4;PIK3CD;ITGAV;MAPK3;WNT11;SDC1;CDC42;FGF2;ROCK2 |
| Small cell lung cancer | CCND1;IKBKB;CASP9;FHIT;IKBKG;ITGA2B;TRAF2;LAMC2;CCNE2 |
| Hypertrophic cardiomyopathy (HCM) | EMD;ITGA9;ITGB6;TTN;CACNA2D2;ITGA5;ITGA1;TNNI3;IGF1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | EMD;AASS;LMNA;TCF7L2;ITGAV;CDH2;ITGB1;CACNB1;DES |
| Dilated cardiomyopathy | TTN;ACTB;TGFB2;DES;ITGB3;TPM3;MYH7;TGFB1;TNF |
ITGB1 has several biochemical functions, for example, actin binding, cell adhesion molecule binding, collagen binding involved in cell-matrix adhesion. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB1 itself. We selected most functions ITGB1 had, and list some proteins which have the same functions with ITGB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | EPB41L3A;FHOD3;VMHCL;HIP1;CXCR4;SMTN;DAAM1;SMYHC2;CCR5 |
| cell adhesion molecule binding | MSN;LPHN1;CAML;NPTN;GRIN2A;PVRL4;CD1d1;NLGN1;ITGB2 |
| collagen binding involved in cell-matrix adhesion | ITGB1;ITGA2;ITGA1;ITGA10;Itga10&Itgb1 |
| fibronectin binding | ITGA4;MYOC;SFRP2;MMP13;CTSS;CTSL1;ITGB1A;ITGA3;IGFBP5A |
| integrin binding | ADAM22;ADAM25;TLN1;COL16A1;Tcam1;COL3A1;GPNMB;VCAM1;S1PR3 |
| laminin binding | ITGA9;ITGA7;ACHE;LGALS1;PLEKHA2;LGALS2A;ITGB1;NCL;BCAM |
| metal ion binding | CYP2V1;JADE3;ZNF839;MYOC;GATA5;ADAP2;ELMSAN1A;RNF216;GFI1B |
| protease binding | INS1;Serpina1b;SERPINA1;ELANE;ALPI;INS;SERPINB4;XBP1;TIMP2B |
| protein binding | NUMBL;GDPD5;PTPN23;FCHSD2;PSMD7;ZC3HC1;HGF;KRTAP3-1;PTGFRN |
| protein heterodimerization activity | HIST3H2BB;TP53;GRIN2A;TLR1;ATF1;BOK;CREB3L3;CENPA;INHBA |
| virus receptor activity | ITGA5;HSPA1A;SERPINB4;ITGB3;ACE2;TNFRSF14;HTR2A;DAG1;CD80 |
ITGB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB1.
FLNA; ITGA5; VCAM1; ITGA4
Research Area
Related articles
- Q&As
- Reviews
Q&As (6)
Ask a questionTherapeutic strategies for ITGB1 protein may include inhibiting its expression, blocking its binding to ligands, or regulating its associated signal transduction pathways. These methods may have potential applications in cancer treatment.
The ITGB1 protein can interact with a variety of other proteins, including ligands, proteins in signal transduction pathways, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.
In cancer, ITGB1 protein may play a role by promoting processes such as the proliferation, migration and invasion of tumor cells, thus promoting the occurrence and development of tumors. It could be a potential target for cancer treatment.
The main function of ITGB1 protein in cells is to act as a cell adhesion receptor, participate in the interaction between cells and extracellular matrix, and play an important role in cell migration and signal transduction.
The structure of the ITGB1 protein determines its ability and stability to bind to ligands. The study of its structure can help us understand its function and mechanism of action.
Recent literature has shown that the expression level of ITGB1 protein is related to the occurrence and development of a variety of diseases, including cancer, cardiovascular diseases, neurodegenerative diseases, etc.
Customer Reviews (3)
Write a reviewThe range of applications for ITGB1 is impressive, and it can play an important role in any field.
ITGB1 performed very well in Western blot, with clear bands and improved experimental accuracy.
ITGB1 has a strong desensitization potential for specific allergens.
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