MAPK1
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Official Full Name
mitogen-activated protein kinase 1
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Overview
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. -
Synonyms
ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1;
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- C
- Myc
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- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPK1 Related Articles
- MAPK1 Related Signal Pathway
MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | PLA2G4A;ATF4;ATF4B1;GADD45AA;IKBKG;ARR3A;RPS6KA2;MAP2K2;MAP2K4A |
| ErbB signaling pathway | MAPK8;PIK3R3A;CDKN1BA;CAMK2B1;ERBB3A;BRAF;ARAF;PRKCBA;KRAS |
| Ras signaling pathway | FGF14;PLD1;PAK1;PAK3;SHOC2;PLA2G4A;GRIN2A;RAP1A;TEK |
| Rap signaling pathway | CALML3;RASGRP3;INS2;RAPGEF5;RAC2;INS;FGF18;GRIN2B;KRIT1 |
| cGMP-PKG signaling pathway | TRPC6;BAD;ITPR1;MAPK1;VASP;CREB3L1;AGTR1B;ATP2A2;PLCB2 |
| cAMP signaling pathway | MAPK1;HCAR2;CNGA1;NFATC1;PPARA;PAK1;RHOA;CREB3L3;CREB3L1 |
| Chemokine signaling pathway | CXCL9;RAC1;NFKBIB;BRAF;GNB4;KRAS;PTK2;CCL1;GNAI2 |
| HIF- signaling pathway | TCEB1;MKNK2;Trf;PIK3CB;HK1;PDHB;PRKCA;INSR;NOX1 |
| FoxO signaling pathway | MAPK13;GABARAPL1;FASLG;PDPK1B;SGK1;HRASA;G6PCA.2;PIK3R2;ATG12 |
| Sphingolipid signaling pathway | DEGS1;SGMS1;ABCC1;PIK3R1;GNA12;RHOA;AKT2;PIK3R5;NSMAF |
| Phospholipase D signaling pathway | GRM4;GRM1;INS1;PLCB2;TSC1;KIT;PTK2B;PDGFB;AKT2 |
| Oocyte meiosis | CALM1A;FBXO43;CDC23;CALM2;SMC1A;PLCZ1;ANAPC11;CPEB1B;CCNE1 |
| mTOR signaling pathway | MAPK3;RPTOR;TSC2;TSC1;PRKCBB;INS1;PRKCBA;TNF;MTOR |
| PIK-Akt signaling pathway | HGF;NGF;INS1;IL2RB;PPP2R2D;PDPK1;GNG5;TNC;CREB3L1 |
| Adrenergic signaling in cardiomyocytes | PPP2R1A;GNA15.1;CAMK2G1;PPP1CAA;ATP2A2;MYL3;PRKCA;PRKACAB;CACNB3A |
| Vascular smooth muscle contraction | PLA2G4F;PPP1CAA;ADCY1B;CALM2B;GNA15.1;ROCK1;PLA2G1B;CALM3B;PRKCH |
| Dorso-ventral axis formation | ETV7;CPEB4;CPEB1;ETV6;MAPK3;MAPK1;ETS1;NOTCH4;PIWIL1 |
| TGF-beta signaling pathway | CHRD;GDF5;BMP2;BMPR2A;RHOAC;BMPR1BB;SMAD6;RBL1;INHBA |
| Axon guidance | TRPC7;SCN2A;CSK;EPHA8;PAK6;DPYSL3;SCN3B;SPTA1;L1CAM |
| VEGF signaling pathway | CDC42;PRKCBA;PTK2AA;RAC1B;RAC3;NFATC2;PIK3R3B;SPHK1;MAPK12A |
| Osteoclast differentiation | CYBB;IFNAR1;PIK3R2;TRAF6;IFNAR2;PPARG;LILRB1;MAP2K7;TEC |
| Focal adhesion | ROCK2B;MYL12B;RHOB;SRC;RAC3B;IGF1RA;MYLK3;PTK2;ARHGAP5 |
| Adherens junction | LMO7A;YES1;RAC3;PVRL2;PTPRM;MAP3K7;CTNNA1;CREBBP;PVRL3 |
| Gap junction | GNA11B;PRKCBB;CSNK1DB;TUBA8;PLCB3;TUBA3C;GJD2;PDGFC;PRKCBA |
| Signaling pathways regulating pluripotency of stem cells | PIK3CD;ESRRB;SMAD5;TBX3;WNT8A;SMAD9;WNT9A;APC;NODAL |
| Platelet activation | ROCK1;PIK3CB;Adcy4;MYL12B;ORAI1;FCER1G;BTK;VWF;MYLK3 |
| Toll-like receptor signaling pathway | MYD88;IL8L2;IFNA10;IKBKE;CD14;FADD;TLR7;TLR1LB;IFNA3 |
| NOD-like receptor signaling pathway | PSTPIP1B;TNF;MAPK12B;CCL5;HSP90AA1.2;PSTPIP1A;MAPK12A;TRAF6;MAPK1 |
| Natural killer cell mediated cytotoxicity | CD247;MICA;PIK3R1;FCGR3;SHC2;MAPK3;MAPK1;MAP2K2;ITGAL |
| T cell receptor signaling pathway | SHB;ZAP70;PIK3CG;GRB2;CD8A;VAV3;DLG1;DBNLB;TNF |
| B cell receptor signaling pathway | NEDD9;FOS;PPP3R2;PPP3CC;CDK2;PIK3CB;ACTR3;ARPC2;CD22 |
| Fc epsilon RI signaling pathway | RAF1;RAC3;SYK;MAP2K3;MAP2K2;FYN;MAP2K1;MAP2K7;MAP2K6 |
| Fc gamma R-mediated phagocytosis | HCK;PIK3CA;PIK3CG;VAV3;PPAP2C;PLA2G4F;PIP5K1C;FCGR1;ASAP1 |
| TNF signaling pathway | MAP2K1;Casp3;PIK3R1;PIK3R3;BAG4;TRAF5;BIRC2;MAP3K7IP3;PIK3R5 |
| Circadian entrainment | PLCB3;GNG3;AKR1C1;GNAI3;GRIA3;GNB4;CACNA1H;GNB1;PRKCG |
| Long-term potentiation | GRIN2B;RPS6KA3;CAMK4;BRAF;RPS6KA2;PPP1CC;GRIA1;RAF1;PLCB2 |
| Neurotrophin signaling pathway | PIK3R1;PIK3CB;RAP1A;PIK3CG;MAP3K5;RIPK2;PIK3CA;SOS1;AKT1 |
| Retrograde endocannabinoid signaling | Adcy4;MAPK10;PLCB2;GRM5;GNG2;GNB2;PRKCB;PLCB4;MAPK13 |
| Glutamatergic synapse | GNB2;GNB4;SLC17A6;SLC1A7;GNG8;GRM5;HOMER2;SLC38A3;GRM7 |
| Cholinergic synapse | GNG2;ACHE;PIK3R3;MAPK1;GNG3;GNAI2;CHAT;KCNQ4;PRKCG |
| Serotonergic synapse | ALOX5;CYP2J6;ALOX15;CYP2C39;ALOX8;HTR7;PRKCB;CYP2C55;CYP2C50 |
| Long-term depression | RAF1;GUCY1B3;GNAQ;PLCB2;GRM1;CRHR1;PLA2G4F;PRKCB;PLCB3 |
| Regulation of actin cytoskeleton | FGF6A;HRASB;FGF20;PAK2B;PIK3CD;TMSB4Y;CYFIP2;RHOAA;ARHGEF7 |
| Insulin signaling pathway | FLOT1;GSK3AA;CALM3;SHC4;PIK3R3;CALM;INPP5K;TSC1B;PHKB |
| GnRH signaling pathway | ADCY1A;MAPK12B;GNA11;LHB;PLCB3;MAPK13;CALM1A;MAPK14B;CALM2B |
| Progesterone-mediated oocyte maturation | Adcy4;CDC26;MAPK3;MAPK8B;CDC16;ANAPC13;CDK1;PRKACAB;RAF1 |
| Estrogen signaling pathway | HSPA2;RAF1;GNAI1;GNAI3;PLCB2;HSP90B1;GNAS;PIK3CG;PIK3R5 |
| Melanogenesis | TYRP1B;CALM2B;RAF1A;GSK3B;RAF1;PLCB2;WNT8A;Adcy4;GSK3AA |
| Prolactin signaling pathway | SOS1;TNFRSF11A;MAPK13;LHB;TNFSF11;FOXO3;STAT1;SOCS6;STAT5A |
| Thyroid hormone signaling pathway | MED24;SRC;SLC9A1;KRAS;ATP1B3;MED12;PIK3CG;NCOR1;RXRB |
| Oxytocin signaling pathway | PRKAG1;ROCK2;MAP2K5;PRKAB2;CAMK2G;PPP3R1;PIK3R3;CALM3;CAMKK2 |
| Type II diabetes mellitus | PIK3CD;TNF;INS;INS1;PDX1;CACNA1G;SOCS1;MAPK10;PIK3CG |
| Aldosterone-regulated sodium reabsorption | ATP1A2;SCNN1B;PIK3CG;PIK3R1;INSR;FXYD2;SLC9A3R2;PIK3CA;PIK3R5 |
| Alzheimers disease | IDE;ATP5C1;NDUFC2-KCTD14;CASP9;SDHD;NDUFA3;CHP;ERN1;NDUFA4 |
| Prion diseases | PRKACA;IL1A;IL1B;CCL5;C1QA;MAP2K1;BAX;PRNP;C9 |
| Alcoholism | HIST1H4F;GNG2;HIST1H4K;HIST1H4E;H2AFZ;GNG8;GM14476;RAF1;HIST1H4B |
| Shigellosis | ELMO3;ACTG1;ITGA5;IL-8;BTRC;CD44;ATG5;IKBKG;NFKBIB |
| Salmonella infection | KLC1B;RAC1;NOS2B;CDC42;MAPK12;MAPK8;RELA;TJP1;PYCARD |
| Pertussis | FOS;TLR4;LY96;Casp3;CALM2;ITGAM;ITGB2L;CFL2;GNAI3 |
| Leishmaniasis | MAPK3;PTPN6;FCGR2C;CR1;FCGR1;FCGR3;C3;TGFB1;IFNGR2 |
| Chagas disease (American trypanosomiasis) | PPP2R1A;SERPINE1;TNFRSF1A;TRAF6;IKBKG;CXCL8;TLR4;CD3E;CALR |
| Toxoplasmosis | HSPA1L;HSPA1A;CASP9;GNAI2;IRGM;LAMA4;LAMA3;MAPK12;MAPK13 |
| Tuberculosis | IFNA6;CALM4;CD14;ARHGEF12;HLA-DQA1;CLEC7A;IL6;Il23a;HLA-DOB |
| Hepatitis C | PPP2R2A;CLDN8;RELA;PPP2CB;OCLN;PDPK1;CLDN9;NR1H3;NFKB1 |
| Hepatitis B | HSPG2;IKBKB;CCNA1;IFN-a;APAF1;IFNA6;FAS;NFATC4;TP53 |
| Influenza A | IFNA16;PRSS3;HSPA6;NFKB1;MAP2K2;IFNA10;IFNA5;PIK3CB;NXF1 |
| Pathways in cancer | FGF18;WNT4;LAMB3;STK4;TGFB1;AHA-1;RAC2;MITF;PIK3R3 |
| Viral carcinogenesis | TRAF1;DLG1;CREB3L1;CCND1;HIST1H4E;HIST1H4A;PIK3R2;STAT5B;CCND3 |
| Proteoglycans in cancer | PLCG1;FGF2;HOXD10;FZD7;TRP53;THBS1;MRAS;PXN;CAMK2B |
| MicroRNAs in cancer | WNT3;TTC6;CDC25B;ZFPM2;WNT3A;HRAS;PRKCE;PDGFRA;ITGB3 |
| Colorectal cancer | KRAS;TGFB3;LEF1;RAC2;MAP2K1;PIK3CB;GSK3B;RALGDS;TCF7L2 |
| Renal cell carcinoma | TCEB2;GAB1;RAP1B;PAK6;KRAS;FLCN;VHL;SLC2A1;PAK7 |
| Pancreatic cancer | PIK3CG;ARAF;RB1;MAPK3;IKBKG;PIK3CB;NFKB1;SMAD3;MAPK1 |
| Endometrial cancer | PIK3CB;CCND1;NRAS;SOS1;HRAS;GRB2;BRAF;MAP2K1;TRP53 |
| Glioma | PDGFRB;BRAF;SHC1;PDGFRA;Pdgfa&Pdgfb;CAMK2B;CALML3;KRAS;SHC3 |
| Prostate cancer | CCNE1;PIK3CG;INSRR;AKT2;CREB3L2;PIK3R5;NFKB1;NKX3-1;CASP9 |
| Thyroid cancer | PAX8;NCOA4;TP53;MAP2K2;NRAS;NTRK1;RXRG;TCF7L2;CCND1 |
| Melanoma | RB1;FGF9;BAD;PIK3CA;RAF1;MDM2;FGF2;PDGFRA;PTEN |
| Bladder cancer | EGF;TYMP;ARAF;RAF1;CDKN2A;MAP2K1;FGFR3;E2F2;HRAS |
| Chronic myeloid leukemia | IKBKB;SHC4;PIK3CA;BRAF;CRK;RELA;HDAC1;SHC1;TGFB3 |
| Acute myeloid leukemia | TCF7L2;MTOR;MAP2K2;LEF1;AKT1;PIM2;RAF1;STAT5A;CEBPA |
| Non-small cell lung cancer | PIK3CA;GRB2;RARB;PIK3R2;PRKCB;PRKCG;RXRA;RASSF5;BAD |
| Central carbon metabolism in cancer | HIF1A;NTRK3;PIK3CB;PFKL;PDGFRB;G6PDX;C12orf5;HK3;MAP2K1 |
| Choline metabolism in cancer | RAC1;MAPK3;SLC22A3;NRAS;PPAP2A;DGKG;MAPK10;WAS;AKT1 |
MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSPA9;CAMK2D1;FES;CHKB;PKM;ACTC1A;HSPA2;RAD51B;ATP1A1 |
| DNA binding | OASL1;HIST1H4K;ZNF285A;DLX2A;HOXB8A;HOXA13B;FOXQ2;GLYR1;HIST1H4H |
| MAP kinase activity | NLK2;MAPK14A;MAPK7;NLK;MAPK13;MAPK1;MAPK15;NLK1;MAPK14B |
| RNA polymerase II carboxy-terminal domain kinase activity | CDK12;CDK7;CDK9;CDK8;MAPK1;CCNK;CDK13;CDK1 |
| mitogen-activated protein kinase kinase kinase binding | PPEF2;DUSP19;STK38;MAPK1;MAP4K2;TRAF2;CDC42;MAPK9;MAP2K1 |
| phosphatase binding | ELFN2;SYTL2;DZIP3;DLG1;KLRAQ1;PPP1R26;ELL;TPRN;SH3GL1 |
| phosphotyrosine binding | LDLRAP1;SHC1;CBL;STAP1;MAPK3;GRB2;ACP2;MAPK1;ZAP70 |
| protein binding | IL4R;ZNF649;IKZF2;SCRT1;FUS;TAE1;SNX10;FKBP4;BEX1 |
| protein serine/threonine kinase activity | CDK5;MAPK12;ACVR1BA;TRIOA;DYRK2;NEK11;MAP2K2A;ULK2;NEK8 |
| transcription factor binding | DIP2BA;SIRT1;CAMTA2;TRIM6;NR0B2A;HDAC5;DDIT3;GCM1;NEUROD1 |
MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.
PTPN7; RPS6KA3; DUSP1; MAPK14
Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).
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Q&As (5)
Ask a question
Can MAPK1 be used as a biomarker for cancer diagnosis?
12/28/2021
MAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.
How can MAPK1 be targeted in drug development for non-cancer conditions?
11/03/2021
MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.
In what other clinical conditions is MAPK1 relevant?
01/12/2020
MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.
Are there targeted therapies that inhibit MAPK1 for cancer treatment?
10/27/2018
Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.
Can MAPK1 be used for personalized medicine approaches?
08/19/2017
Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.
Customer Reviews (3)
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03/24/2022
Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.
03/26/2021
In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.
03/11/2020
The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.
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