ZAP70
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Official Full Name
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
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Synonyms
ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK, zeta chain (TCR) associated protein kinase (70 kD); tyrosine-protein kinase ZAP-70; STD; ZAP 70; syk-related tyrosine kinase; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; zeta-chain associated protein kinase, 70kD; SRK; FLJ17670; FLJ17679; ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; TZK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein Syk-related tyrosine kinase; EC 2.7.10.2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ZAP70 Related Articles
- ZAP70 Related Research Area
ZAP70 involved in several pathways and played different roles in them. We selected most pathways ZAP70 participated on our site, such as Ras signaling pathway, NF-kappa B signaling pathway, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZAP70 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | PLA2G3;SHC3;PDGFB;BRAP;FGF8;GRIN1;PLA2G4C;FGF16;MAPK3 |
NF-kappa B signaling pathway | IRAK1;TRIM25;CXCL2;TAB2;CCL21B;IL-8;CD14;Ccl21a;CCL13 |
Natural killer cell mediated cytotoxicity | HCST;PPP3R1;SHC1;PTPN11;CD244;KIR3DL1;HLA-C;KIR2DS4;SHC4 |
T cell receptor signaling pathway | MAP3K7;CD8B;MAPK13;CD40LG;CBLC;DEF6A;RAF1;MAPK12;SOS1 |
Primary i | CD40LG;CD79A;IL2RG;Cd79a, Cd79b;IL7R;ICOS;RAG1;TAP2;CD19 |
nodeficiency | CD19;ORAI1;AIRE;RFXANK;PTPRC;CD3D;CD40;TAP2;ICOS |
ZAP70 has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZAP70 itself. We selected most functions ZAP70 had, and list some proteins which have the same functions with ZAP70. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ABCB11;SBK3;MVK;NLRC3;TAE1;ERBB4A;RAD51;PDPK1;PRKCD |
non-membrane spanning protein tyrosine kinase activity | SRMS;CSK;JAK2;EIF2AK2;ABL2;HCK;FER;SRC;BLK |
phosphotyrosine binding | FGR;SAMSN1;STAP1;CBL;PTPN3;CBLB;SHC1;GRB2;MAPK3 |
protein binding | INCA1;PTPN11A;RFWD2;FAM108A1;EPHA10;DPP3;SIX3;TRIM6;PPM1B |
protein tyrosine kinase activity | TYK2;MAP3K9;DYRK1A;DYRK3;FGR;BCR;BAZ1B;PTK7;FES |
receptor binding | MIF;CADM4;LYN;GDNF;CD72;FGF8B;DDX54;HCK;UTS2 |
ZAP70 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZAP70 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZAP70.
CD247
- Q&As
- Reviews
Q&As (5)
Ask a questionResearch is ongoing to determine whether ZAP70 levels can predict the response of cancer patients to immunotherapy, particularly in T-cell-related treatments.
ZAP70's involvement in T-cell activation makes it relevant in cancer immunotherapy, where it can be targeted to enhance anti-tumor immune responses.
Yes, ZAP70 testing can identify mutations or deficiencies that may contribute to immunodeficiency disorders, aiding in diagnosis and treatment planning.
ZAP70 expression can be measured through flow cytometry or molecular techniques, providing quantitative information for diagnosis and prognosis.
Yes, ongoing research aims to explore new clinical applications of ZAP70, including its potential in personalized medicine and targeted therapies.
Customer Reviews (3)
Write a reviewTheir team of experts is not only knowledgeable about the ZAP70 protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.
Whether it's modifying protocols, providing custom formulations, or offering personalized recommendations, their flexibility ensures that I have the necessary tools to carry out my experiments seamlessly.
This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.
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