Description : |
Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA. |
Source : |
E. coli |
Species : |
Hepatitis B Virus |
Form : |
7.5mM Phosphate buffer pH-7.2, 75mM NaCl, & 50% glycerol. |
Molecular Mass : |
14kDa |
Protein length : |
amino acids 1-144 |
Purity : |
HBV Core Delta protein is >95% pure as determined by SDS-PAGE (coomassie staining). |
Applications : |
HBV Core Delta antigen is suitable for ELISA and Western blots, excellent antigen for detection of HBV with minimal specificity problems. |
Usage : |
The products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
Specificity : |
Immunoreactive with sera HBV-infected individuals. |
Storage : |
HBV Core Delta protein although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze thaw cycles. |
Shipping : |
Ice Packs |