Recombinant Human C10orf54 protein, His-tagged
Cat.No. : | C10orf54-313H |
Product Overview : | Recombinant Human C10orf54(Phe33-Ala194) fused with an Asp187Glu substitution and a C-terminal 6-His tag was expressed in NS0. |
- Specification
- Gene Information
- Related Products
Description : | Platelet receptor Gi24, also known as Dies1, VISTA, SISP1 and B7-H5, is a 55-65 kDa transmembrane glycoprotein with homology to B7-like immune costimulatory molecules. Mature human Gi24 contains a 162 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane segment, and a 96 aa cytoplasmic domain. Within the ECD, human Gi24 shares 70% and 67% aa sequence identity with mouse and rat Gi24, respectively. The 30 kDa ECD can be shed by MT1-MMP, with a 25-30 kDa fragment remaining in the membrane. Gi24 promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. Gi24 supports the differentiation of embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC, but is also down-regulated following BMP-4 exposure. It binds to BMP-4 directly, and also associates with the type I BMP receptor Activin RIB/ALK-4 (4, 5). Gi24 is expressed on the surface of naïve CD4+ T cells, regulatory T cells, and adipocytes. It is up-regulated in vivo on activated monocytes and dendritic cells. Gi24 inhibits CD4+ and CD8+ T cell proliferation, and their production of IL-2 and IFN-gamma. Its expression on tumor cells attenuates the anti-tumor immune response and enables more rapid tumor progression. In contrast, Gi24 limits disease progression in the autoimmune disease model EAE. Gi24 also acts as a co-inhibitory receptor on alloreactive T cells to regulate T cell tolerance. |
Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Phe33 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Molecular Mass : | Predicted Molecular Mass: 19 kDa; SDS-PAGE: 30-65 kDa, reducing conditions. |
Protein length : | Phe33-Ala194 |
Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 200 μg/mL in PBS. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Gene Name : | C10orf54 chromosome 10 open reading frame 54 [ Homo sapiens ] |
Official Symbol : | C10orf54 |
Synonyms : | C10ORF54; chromosome 10 open reading frame 54; platelet receptor Gi24; B7 H5; GI24; SISP1; stress induced secreted protein 1; B7-H5; PP2135; |
Gene ID : | 64115 |
mRNA Refseq : | NM_022153 |
Protein Refseq : | NP_071436 |
UniProt ID : | Q9H7M9 |
Chromosome Location : | 10q22.1 |
Function : | receptor activity; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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