Active Recombinant Human DNMT3A/DNMT3L Complex, His/GST-tagged
Cat.No. : | DNMT3A/DNMT3L-0293H |
Product Overview : | Recombinant Human DNMT3A(a.a 623-912) fused with His tag at N terminal and DNMT3L(a.a. 160-387) fused with GST tag at N terminal complex was co-expressed in a baculovirus-infected Sf9 cell expression system. |
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Source : | Insect cells |
Species : | Human |
Tag : | His/GST |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 16 mM glutathione and 20% glycerol. |
Bio-activity : | ≥0.58 pmol/min/µg. |
Molecular Mass : | DNMT3A: 34 kDa; DNMT3L: 52 kDa |
Purity : | > 95% |
Applications : | Useful for the study of DNA methylation, screening inhibitors, and selectivity profiling. |
Storage : | >6 months at –80 centigrade. Avoid freeze/thaw cycles. |
Gene Name : | DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ] |
Official Symbol : | DNMT3A |
Synonyms : | DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2; DNMT3A2; M.HsaIIIA; |
Gene ID : | 1788 |
mRNA Refseq : | NM_175629 |
Protein Refseq : | NP_783328 |
MIM : | 602769 |
UniProt ID : | Q9Y6K1 |
Chromosome Location : | 2p23 |
Pathway : | Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserved biosystem; One Carbon Metabolism, organism-specific biosystem; Validated targets of C-MYC transcriptional repression, organism-specific biosystem; |
Function : | DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA binding; chromatin binding; metal ion binding; methyltransferase activity; protein binding; transferase activity; unmethylated CpG binding; |
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DNMT3A-1585R | Recombinant Rat DNMT3A Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DNMT3A-6855HCL | Recombinant Human DNMT3A 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDNMT3A mutations can serve as biomarkers for certain cancers, aiding in the diagnosis and classification of hematologic malignancies.
DNMT3A is essential for normal DNA methylation patterns during development and differentiation, influencing gene expression and cellular function.
Like many targeted therapies, DNMT3A-targeted treatments may have off-target effects, and their specificity is an area of active research.
Yes, molecular diagnostic tests, such as DNA sequencing, can identify DNMT3A mutations in cancer cells.
DNMT3A mutations lead to abnormal DNA methylation patterns, contributing to altered gene expression and promoting cancer development.
Customer Reviews (3)
Write a reviewIts exceptional characteristics, coupled with the manufacturer's commitment to customer satisfaction, ensure that I can pursue my scientific investigations with confidence and success.
Its consistent performance and reproducibility have been praised by scientists who have employed it in their studies, with many reporting outstanding results and a high level of satisfaction.
This level of support becomes invaluable, allowing researchers to focus on their scientific objectives while receiving expert guidance alongside.
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