Recombinant Human WEE1 protein, MYC/DDK-tagged

• Cat.No.: WEE1-36H
• Product Overview: Recombinant Human WEE1, transcript variant 1, fussed with MYC/DDK at C-terminal was expressed in HEK293.

Specification

• Description: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 71.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: WEE1 WEE1 G2 checkpoint kinase [ Homo sapiens ]
• Official Symbol: WEE1
• Synonyms: WEE1A; WEE1hu; wee1-like protein kinase; WEE1 homolog; WEE1+ homolog; wee1A kinase
• Gene ID: 7465
• mRNA Refseq: NM_003390
• Protein Refseq: NP_003381
• MIM: 193525
• UniProt ID: P30291
• Chromosome Location: 11p15.4
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle - G2/M transition, conserved biosystem
• Function: ATP binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity

Reviews

07/10/2019

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12/12/2018

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02/12/2018

Reliable partner in experiments. Highly recommended for research.

Q&As

How does WEE1 contribute to DNA damage response?

It plays a role in DNA damage response by delaying cell cycle progression to allow DNA repair.

What is the impact of altered WEE1 activity on cancer development?

Altered WEE1 activity is associated with the progression of various cancers.

What potential therapeutic applications arise from targeting WEE1 in cancer treatment?

Targeting WEE1 in cancer therapy could exploit its role in cell cycle regulation to inhibit tumor growth.

How do genetic variations in WEE1 affect cell division?

Genetic mutations in WEE1 can lead to uncontrolled cell division and genomic instability.

What role does WEE1 play in checkpoint regulation?

WEE1 is critical in checkpoint regulation, ensuring cells do not divide with damaged DNA.

How does WEE1 interact with other cell cycle proteins?

WEE1 works in conjunction with other cell cycle proteins to regulate the timing of cell division.

What is the primary role of WEE1 in cell cycle control?

WEE1 is a kinase that inhibits cell cycle progression, particularly at the G2/M checkpoint.