Recombinant Full Length Arabidopsis Thaliana Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged
Cat.No. : | RFL31382AF |
Product Overview : | Recombinant Full Length Arabidopsis thaliana GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase(ALG11) Protein (Q9XEE9) (1-463aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Arabidopsis thaliana (Mouse-ear cress) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-463) |
AA Sequence : | MAIYFILYTLLTIIFAVSLSLFLSV INARKSRKRAVGFFHPYTNDGGGGE RVLWCAVKAI QEENPDLDCVIFTGDHDSSSDSLAR RAVDRFGVHLQSPPKVIHLNKRKWI EESTYPHFTM IGQSLGSVYLAWEALRMFTPLYFLD TSGYAFTYPLARIFGCKVVCYTHYP TISLDMISRV RQRNSMYNNDASIAKSNWLSTCKLV YYRAFSWMYGMVGSCTHLAMVNSSW TKSHIEVLWR IPERITRVYPPCDTSGLQAFPLERS SDPPKIISVAQFRPEKAHMLQLEAF SLALEKLDAD VPRPKLQFVGSCRNNSDEERLQKLK DRAVELKVDGDVQFYKNAMYRELVE LLGNAVAGLH GMIDEHFGISVVEYMAAGAIPIAHN SAGPKMDIVLEEDGQKTGFLAETVE EYAEAILEIV KMNETERLKMAESARKRAARFSEQR FCEDFKTAIRPIFTGPLK |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | ALG11 |
Synonyms : | ALG11; LEW3; At2g40190; T07M07.7; GDP-Man:Man(3GlcNAc(2-PP-Dol alpha-1,2-mannosyltransferase; Alpha-1,2-mannosyltransferase ALG11; Asparagine-linked glycosylation protein 11; Protein LEAF WILTING 3 |
UniProt ID : | Q9XEE9 |
Gene Name : | ALG11 |
Synonyms : | ALG11; LEW3; At2g40190; T07M07.7; GDP-Man:Man(3GlcNAc(2-PP-Dol alpha-1,2-mannosyltransferase; Alpha-1,2-mannosyltransferase ALG11; Asparagine-linked glycosylation protein 11; Protein LEAF WILTING 3 |
UniProt ID : | Q9XEE9 |
Products Types
◆ Recombinant Protein | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionSome ALG11 mutations may lead to central nervous system diseases, such as cerebral cortex atrophy, etc. However, a large number of studies are needed to support the adequacy and validity of the above relationship.
The effects of ALG11 defects on cell life activities may include metabolic abnormalities, protein synthesis and secretion abnormalities, etc. The mechanism of these effects needs to be further explained.
ALG11 is part of the GMD family and is found in winged animals and other eukaryotes. More studies are needed to confirm the family structure and evolutionary relationship.
The clinical manifestations of patients with ALG11 deficiency syndrome are complicated, and it is necessary to synthesize various evidences, such as clinical symptoms, magnetic resonance, nuclear magnetic resonance, X-ray and other comprehensive evaluation, to determine the specific disease type.
The functional screening of ALG11 gene needs to be based on the special characteristics of its genome sequence and encoded protein, combined with the existing research results, and adopt appropriate screening technology to determine.
The relationship between ALG11 gene and specific matrix substances in the glycosylation process is not completely clear, and further research is needed.
At present, the effects of ALG11 gene defects on the development and reproduction of organisms still need to be explored.
At present, the mechanism of the effect of ALG11 gene mutation on protein glycosylation needs to be studied at the cellular level to elucidate a comprehensive influence model.
ALG11 may be involved in cell membrane regeneration through the modification of membrane glycoproteins, glycolipids, peptides and other molecules.
There is no evidence that ALG11 polymorphisms are associated with other genetic or environmental factors. But research is continuing.
The ALG11 gene is composed of multiple exons that were included in previous genomic sequencing studies. The regulation mechanism still needs to be studied further.
ALG11 gene mutations may be associated with heart disease and other syndromes associated with protein glycosylation. But more research is needed to confirm the evidence.
ALG11 defects may lead to lipid metabolism abnormalities by modifying protein modifications related to lipid metabolism. However, further studies are needed to determine the mechanism.
At present, there are not enough research results on how ALG11 affects the therapeutic mechanism of Cardoria, and more data are needed to support it in the future.
The post-transcriptional modification and expression patterns of ALG11 gene require more biochemical studies to further explain.
The expression of ALG11 gene in different tissues and cell types may vary, please refer to relevant literature.
The mechanism of ALG11 defect and its effect on glycosylation exist a series of complex regulatory mechanisms, which need to be further studied at the molecular and cellular levels.
The ALG11 encoding protein is involved in the process of protein glycosylation, and the details such as what mechanism achieves this process are still in the field of unstudied.
To prevent the regional mutation or sequence variation of ALG11 gene, it is necessary to strengthen the collection and preservation of relevant biological samples, as well as perfect data management and maintenance systems.
More research is needed on the association between the ALG11 gene and lung disease, which has only been a concern in recent years.
Customer Reviews (4)
Write a reviewWidely available and easy to prepare.
Easy to store, more stable.
Compared with other methods, qPCR detection is better.
Easy to purify in production, high purity.
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