ALG2
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Official Full Name
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
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Overview
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. -
Synonyms
ALG2; asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae); asparagine linked glycosylation 2 homolog (yeast, alpha 1,3 mannosyltransferase); alpha-1,3/1,6-mannosyltransferase ALG2; CDGIi; FLJ14511; hALPG2; NET38; OTTHUMP00000123474; 3-mannosyltransferase ALG2; ALG2_HUMAN; Alpha 1,3 mannosyltransferase ALG2; Alpha-1; Asparagine linked glycosylation protein 2; Asparagine-linked glycosylation protein 2 homolog; GDP Man:Man(1)GlcNAc(2) PP dolichol mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; OTTHUMP00000021785; RP11-13B9.1; homolog of yeast ALG2; alpha-1,3-mannosyltransferase ALG2; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
- Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
- Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
- Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
- Mouse
- Mus musculus (Mouse)
- Rhesus Macaque
- Rhizomucor pusillus
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
- Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
- Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALG2-9575H | Recombinant Human ALG2, His-tagged | E.coli | His | C-term-292a.a. | |
Human | ALG2-463H | Recombinant Human ALG2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ALG2-8906HCL | Recombinant Human ALG2 293 Cell Lysate | HEK293 | N/A | ||
Human | ALG2-1432HF | Recombinant Full Length Human ALG2 Protein, GST-tagged | In Vitro Cell Free System | GST | 416 amino acids | |
Human | ALG2-6198H | Recombinant Human ALG2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | ALG2-01H | Recombinant Human ALG2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | ALG2-1546M | Recombinant Mouse ALG2 Protein | Mammalian Cell | His | ||
Mouse | Alg2-1598M | Recombinant Mouse Alg2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | ALG2-466M-B | Recombinant Mouse ALG2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ALG2-466M | Recombinant Mouse ALG2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) | RFL10673AF | Recombinant Full Length Ashbya Gossypii Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-514) | |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) | RFL6598CF | Recombinant Full Length Candida Albicans Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-428) | |
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) | RFL20885CF | Recombinant Full Length Candida Glabrata Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-458) | |
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) | RFL3268DF | Recombinant Full Length Debaryomyces Hansenii Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-476) | |
Dictyostelium discoideum (Slime mold) | RFL5561DF | Recombinant Full Length Dictyostelium Discoideum Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-420) | |
Homo sapiens (Human) | RFL29126HF | Recombinant Full Length Human Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-416) | |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) | RFL24514KF | Recombinant Full Length Kluyveromyces Lactis Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-503) | |
Mus musculus (Mouse) | RFL24227MF | Recombinant Full Length Mouse Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-415) | |
Rhesus Macaque | ALG2-303R | Recombinant Rhesus monkey ALG2 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ALG2-131R-B | Recombinant Rhesus Macaque ALG2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | ALG2-131R | Recombinant Rhesus Macaque ALG2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhizomucor pusillus | RFL19171RF | Recombinant Full Length Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-455) | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RFL35427SF | Recombinant Full Length Saccharomyces Cerevisiae Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-503) | |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | RFL25299SF | Recombinant Full Length Schizosaccharomyces Pombe Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-511) | |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) | RFL1068YF | Recombinant Full Length Yarrowia Lipolytica Alpha-1,3/1,6-Mannosyltransferase Alg2(Alg2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-460) | |
Zebrafish | ALG2-5978Z | Recombinant Zebrafish ALG2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ALG2 involved in several pathways and played different roles in them. We selected most pathways ALG2 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Asparagine N-linked glycosylation | NANP;ST8SIA2;ANKRD28;SEC23A;OS9;NAPB;CNIH3;TRAPPC4;MCFD2 |
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ST8SIA2;MPDU1A;ST6GAL2B;ZNF408;DPAGT1;NEU4;SLC35A1;ST3GAL3A;NANP |
Metabolic pathways | PCCA;TPI1;Atp5k;CYP4A14;PTGIS;CKM;PIGW;GPAT2;TUSC3 |
Metabolism of proteins | ADD1;DAD1;DPAGT1;B3GNT6;TUBA3D;NEU3;EXOC8;DNAJC24;NSFB |
N-Glycan biosynthesis | ALG5;ALG10B;ALG11;STT3B;B4GALT2;DPAGT1;MAN1C1;MGAT3A;MAN1A2 |
Post-translational protein modification | A4GNT;DPH5;ALG14;GALNT6;PIGK;ADAMTS20;MUC12;MGAT4B;PHC1 |
ALG2 has several biochemical functions, for example, GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity, alpha-1,3-mannosyltransferase activity, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG2 itself. We selected most functions ALG2 had, and list some proteins which have the same functions with ALG2. You can find most of the proteins on our site.
Function | Related Protein |
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GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity | |
alpha-1,3-mannosyltransferase activity | ALG2;DPY19L1;GALNT18A;PIGB;GLT8D1;ALG8;GTDC2;DPY19L4;B3GNT9-PS |
calcium-dependent protein binding | MYO1D;MMP13;S100P;TSG101;ANXA1;MASP1;VLDLR;CLEC4M;S100A11 |
protein N-terminus binding | MEN1;ID1;STXBP1;SNF8;CSNK2A2;LACRT;ERCC2;TARBP2;NFE2 |
protein binding | ZAK;TRP53;CAV2;APP;USP9X;RAB14;PRKAA1;CHEK1;YY1AP1 |
protein heterodimerization activity | HIST3H2BB;KCNA3;DMBX1;MID2;FZD1;MID1;TAF12;NKX2-5;TLX1 |
ALG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG2.
- Q&As
- Reviews
Q&As (18)
Ask a questionThis mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.
ALG2 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.
ALG2 regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG3 and ALG1.
A number of inhibitors have been developed that target ALG2 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.
The catalyzes the sugar chain transfer reaction between UDP-glucose and substrate proteins, synthesizing sugar chains onto proteins.
No studies have confirmed whether ALG2 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.
Although there are currently no studies demonstrating the function of ALG2 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.
ALG2 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.
Overexpression or knockout of ALG2 can negatively affect cellular glycosylation and the stability of ER and Golgi bodies, but the specific effects need to be further explored.
This protein selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.
ALG2 is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.
At present, there is no direct evidence that ALG2 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.
There is currently no direct evidence that ALG2 is associated with neurological diseases, but glycosylation plays a key role in nervous system development and function, so there may be a correlation with neurological diseases.
This gene contains 10 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.
ALG2 is mainly distributed in the endoplasmic reticulum (ER) and the Golgi apparatus.
At present, there is no direct evidence that ALG2 mutations are directly related to some diseases, but glycosylation plays an important role in metabolism and disease development, so it may be related to related diseases.
The protein interacts with members of the glycosylase family such as ALG3, ALG1 and other related proteins to jointly regulate the glycosylation process of proteins.
There is no direct evidence that ALG2 is involved in the occurrence and development of metabolic diseases, but it may be associated with related metabolic diseases.
Customer Reviews (4)
Write a reviewIn immunological experiments, ALG2 was found to have good antigenicity and could induce target immune responses.
The high solubility of ALG2 makes it easy to prepare the desired concentration.
The high catalytic efficiency of ALG2 was found in enzymatic experiments.
It was observed that ALG2 had better crystallinity, which was beneficial for crystallographic studies.
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