Recombinant Full Length Human ACSM2A Protein, GST-tagged

• Cat.No.: ACSM2A-808HF
• Product Overview: Human ACSM2A full-length ORF (BAG53201.1, 1 a.a. - 577 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 89.87 kDa
• Protein Length: 577 amino acids
• AA Sequence: MHWLRKVQGL CTLWGTQMSS RTLYINSRQL VSLQWGHQEV PAKFNFASDV LDHWADMEKA GKRLPSPALW WVNGKGKELM WNFRELSENS QQAANVLSGA CGLQRGDRVA VVLPRVPEWW LVILGCIRAG LIFMPGTIQM KSTDILYRLQ MSKAKAIVAG DEVIQEVDTV ASECPSLRIK LLVSEKSCDG WLNFKKLLNE ASTTHHCVET GSQEASAIYF TSGTSGLPKM AEHSYSSLGL KAKMDAGWTG LQASDIMWTI SDTGWILNIL CSLMEPWALG ACTFVHLLPK FDPLVILKTL SSYPIKSMMG APIVYRMLLQ QDLSSYKFPH LQNCVTVGES LLPETLENWR AQTGLDIRES YGQTETGLTC MVSKTMKIKP GYMGTAASCY DVQIIDDKGN VLPPGTEGDI GIRVKPIRPI GIFSGYVDNP DKTAANIRGD FWLLGDRGIK DEDGYFQFMG RADDIINSSG YRIGPSEVEN ALMEHPAVVE TAVISSPDPV RGEVVKAFVV LASQFLSHDP EQLTKELQQH VKSVTAPYKY PRKIEFVLNL PKTVTGKIQR AKLRDKEWKM SGKARAQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACSM2A acyl-CoA synthetase medium-chain family member 2A [ Homo sapiens ]
• Official Symbol: ACSM2A
• Synonyms: ACSM2; A-923A4.1
• Gene ID: 123876
• mRNA Refseq: NM_001010845.2
• Protein Refseq: NP_001010845.1
• MIM: 614358
• UniProt ID: Q08AH3

Reviews

10/21/2019

So grateful for its performance!

09/14/2019

It seamlessly integrates into our experimental systems, enabling precise control and manipulation. It has greatly expanded the scope of our investigations.

08/08/2019

The functionality of this protein is outstanding.

07/02/2018

Affordable pricing without compromising on quality. Highly satisfied with the product.

05/07/2018

We are exceedingly satisfied with the quality of this protein.

Q&As

What is the role of ACSM2A in cancer metabolism?

Recent studies have suggested that ACSM2A plays a critical role in cancer metabolism by regulating the uptake and utilization of fatty acids by cancer cells.

How is ACSM2A involved in muscle function?

ACSM2A has been shown to be highly expressed in skeletal muscle and may play a role in regulating muscle function and metabolism. Studies have suggested that ACSM2A may be involved in the regulation of glucose uptake and glycogen synthesis in muscle cells.

How does ACSM2A interact with other cellular proteins and signaling pathways?

ACSM2A is known to interact with several cellular proteins and signaling pathways, including the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors and the AMP-activated protein kinase (AMPK) pathway. Further investigation is needed to fully understand the functional significance of these interactions.

What is the mechanism of ACSM2A-mediated insulin resistance?

ACSM2A-mediated insulin resistance is thought to be due to the accumulation of lipid intermediates, such as diacylglycerols and ceramides, which interfere with insulin signaling.

What is the clinical significance of ACSM2A in cancer?

ACSM2A expression has been shown to be upregulated in various types of cancer, including breast cancer and pancreatic cancer, and may serve as a potential therapeutic target for cancer treatment.

How is ACSM2A expression regulated in cancer cells?

Recent studies have suggested that ACSM2A expression is regulated by the tumor microenvironment, including hypoxia and inflammatory cytokines, in cancer cells.

What is the effect of ACSM2A inhibition on colorectal cancer cells?

Inhibition of ACSM2A activity has been shown to suppress the growth and survival of colorectal cancer cells, suggesting that ACSM2A may serve as a potential therapeutic target for colorectal cancer treatment.

What is the mechanism of action of ACSM2A in cancer cells?

The precise mechanism by which ACSM2A regulates tumor growth and survival in cancer cells is not fully understood. However, recent studies suggest that ACSM2A may modulate fatty acid metabolism and mitochondrial function to support cancer cell growth and survival.

What is the role of ACSM2A in liver steatosis?

ACSM2A has been implicated in the development of liver steatosis by promoting the uptake and accumulation of fatty acids in hepatocytes.

What is the effect of ACSM2A deficiency on energy metabolism?

ACSM2A deficiency has been shown to impair mitochondrial β-oxidation and energy metabolism, leading to metabolic dysfunction.