Recombinant Full Length Human ACSS2 Protein, GST-tagged

• Cat.No.: ACSS2-814HF
• Product Overview: Human ACSS2 full-length ORF ( AAH98422.1, 1 a.a. - 606 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 94 kDa
• Protein Length: 606 amino acids
• AA Sequence: MKGATTNICY NVLDRNVHEK KLGDKVAFYW EGNEPGETTQ ITYHQLLVQV CQFSNVLRKQ GIQKGDRVAI YMPMIPELVV AMLACARIGA LHSIVFAGFS SESLCERILD SSCSLLITTD AFYRGEKLVN LKELADEALQ KCQEKGFPVR CCIVVKHLGR AELGMGDSTS QSPPIKRSCP DVQISWNQGI DLWWHELMQE AGDECEPEWC DAEDPLFILY TSGSTGKPKG VVHTVGGYML YVATTFKYVF DFHAEDVFWC TADIGWITGH SYVTYGPLAN GATSVLFEGI PTYPDVNRLW SIVDKYKVTK FYTAPTAIRL LMKFGDEPVT KHSRASLQVL GTVGEPINPE AWLWYHRVVG AQRCPIVDTF WQTETGGHML TPLPGATPMK PGSATFPFFG VAPAILNESG EELEGEAEGY LVFKQPWPGI MRTVYGNHER FETTYFKKFP GYYVTGDGCQ RDQDGYYWIT GRIDDMLNVS GHLLSTAEVE SALVEHEAVA EAAVVGHPHP VKGECLYCFV TLCDGHTFSP KLTEELKKQI REKIGPIATP DYIQNAPGLP KTRSGKIMRR VLRKIAQNDH DLGDMSTVAD PSVISHLFSH RCLTIQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACSS2 acyl-CoA synthetase short-chain family member 2 [ Homo sapiens ]
• Official Symbol: ACSS2
• Synonyms: ACSS2; acyl-CoA synthetase short-chain family member 2; ACAS2, acetyl Coenzyme A synthetase 2 (ADP forming); acetyl-coenzyme A synthetase, cytoplasmic; AceCS; ACS; ACSA; dJ1161H23.1; acetate thiokinase; acetate-CoA ligase; acyl-activating enzyme; cytoplasmic acetyl-coenzyme A synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming); ACAS2; ACECS; DKFZp762G026
• Gene ID: 55902
• mRNA Refseq: NM_001076552
• Protein Refseq: NP_001070020
• MIM: 605832
• UniProt ID: Q9NR19

Reviews

01/09/2022

It showed superior stability, retaining its activity even under challenging experimental conditions. It has significantly improved the reliability of our assays.

11/03/2021

It's a game-changer for any lab seeking efficiency.

09/17/2020

This protein is a rock star! It consistently delivers outstanding results with a smile.

06/12/2019

The quality-price ratio of this protein is truly commendable.

04/28/2018

Its reliable and reproducible results have facilitated precise data acquisition, supporting the validity and integrity of our experimental findings.

Q&As

What is the role of ACSS2 protein in liver metabolism?

ACSS2 protein is required for normal liver metabolism and the synthesis of ketone bodies, which are important energy sources during fasting and starvation

What is the effect of ACSS2 protein inhibition on the response to hypoxia?

Inhibition of ACSS2 protein activity sensitizes cancer cells to hypoxia, a condition of low oxygen availability that promotes tumor progression and resistance to therapy.

What is the relationship between ACSS2 protein and fatty acid metabolism?

ACSS2 protein plays a critical role in linking fatty acid metabolism to oxidative metabolism in the mitochondria of mammalian cells.

What is the role of ACSS2 protein in adipose tissue?

ACSS2 protein plays a key role in adipose tissue metabolism by regulating the production of adipokines, hormones that are involved in the regulation of energy homeostasis.

What is the relationship between ACSS2 protein and aging?

ACSS2 protein expression has been shown to decline with age, and the loss of ACSS2 protein activity may contribute to age-related metabolic dysfunction.

What is the relationship between ACSS2 protein and circadian rhythms?

ACSS2 protein expression is regulated by circadian rhythms, and ACSS2 protein activity may play a role in the circadian regulation of metabolism.

What is the relationship between ACSS2 protein and the gut-brain axis?

Emerging evidence suggests that ACSS2 protein may play a role in the gut-brain axis, which is the bidirectional communication between the gut microbiome and the central nervous system.

What is the relationship between ACSS2 protein and the gut microbiome?

ACSS2 protein expression is regulated by the gut microbiome, and ACSS2 protein activity may play a role in the interaction between the host and the microbiome.

What is the effect of ACSS2 protein deficiency on macrophage function?

Deficiency of ACSS2 protein activity in macrophages has been shown to impair phagocytosis and reduce the production of inflammatory cytokines.

What is the role of ACSS2 protein in the regulation of fatty acid oxidation?

ACSS2 protein is involved in the regulation of fatty acid oxidation by providing the acetyl-CoA needed for entry into the TCA cycle.