ACSS2
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Official Full Name
acyl-CoA synthetase short-chain family member 2
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Overview
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. -
Synonyms
ACSS2; acyl-CoA synthetase short-chain family member 2; ACAS2, acetyl Coenzyme A synthetase 2 (ADP forming); acetyl-coenzyme A synthetase, cytoplasmic; AceCS; ACS; ACSA; dJ1161H23.1; cytoplasmic; ACAS2; Acetate CoA ligase; Acetate thiokinase; Acetate--CoA ligase; Acetyl CoA synthetase; Acetyl Coenzyme A synthetase 2 (ADP forming); Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; Acetyl-coenzyme A synthetase; ACSA_HUMAN; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; Acyl-activating enzyme; Cytoplasmic acetyl coenzyme A synthetase; MYH7B; acetate-CoA ligase; cytoplasmic acetyl-coenzyme A synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
ACSS2 involved in several pathways and played different roles in them. We selected most pathways ACSS2 participated on our site, such as Glycolysis / Gluconeogenesis, Pyruvate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycolysis / Gluconeogenesis | LDHA;BPGM;ADH1B;PFKP;FBP1A;ALDH9A1;PCK2;ADH2-2;MINPP1 |
Pyruvate metabolism | FH1;ALDH9A1A.1;LDHD;PDK2;LDHC;ACAT1;ALDH7A1;hchA;ALDH2.1 |
Propanoate metabolism | SUCLA2;LDHAL6B;HADHA;ACAT1;ackA;HADHAA;MCEE;PCCB;MLYCD |
Metabolic pathways | CYP7A1A;AK5;ENO1A;mt-Atp8;TPH1B;PANK3;SLC27A5;MTHFR;G6PCA.1 |
Carbon metabolism | PGAM1B;MDH1AA;EHHADH;HKDC1;GOT1;TKTB;TPI1A;DLST;PDHA2 |
ACSS2 has several biochemical functions, for example, AMP binding, ATP binding, acetate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSS2 itself. We selected most functions ACSS2 had, and list some proteins which have the same functions with ACSS2. You can find most of the proteins on our site.
Function | Related Protein |
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AMP binding | PRPS2;CYB5R3;PYGL;PRKAG2;FBP1;PRKAG1;PRPS1;APRT;PYGM |
ATP binding | SMG1;MARS2;PRKCBB;PKN3;P2RX4;MYO1F;ULK4;PIM2;ATP10A |
acetate-CoA ligase activity | ACSS3;ACSS2;ACSS1 |
ACSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSS2.
q2i360_hbv; purT; UPF1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; Smchd1; CTR9
- Q&As
- Reviews
Q&As (10)
Ask a questionACSS2 protein is required for normal liver metabolism and the synthesis of ketone bodies, which are important energy sources during fasting and starvation
Inhibition of ACSS2 protein activity sensitizes cancer cells to hypoxia, a condition of low oxygen availability that promotes tumor progression and resistance to therapy.
ACSS2 protein plays a critical role in linking fatty acid metabolism to oxidative metabolism in the mitochondria of mammalian cells.
ACSS2 protein plays a key role in adipose tissue metabolism by regulating the production of adipokines, hormones that are involved in the regulation of energy homeostasis.
ACSS2 protein expression has been shown to decline with age, and the loss of ACSS2 protein activity may contribute to age-related metabolic dysfunction.
ACSS2 protein expression is regulated by circadian rhythms, and ACSS2 protein activity may play a role in the circadian regulation of metabolism.
Emerging evidence suggests that ACSS2 protein may play a role in the gut-brain axis, which is the bidirectional communication between the gut microbiome and the central nervous system.
ACSS2 protein expression is regulated by the gut microbiome, and ACSS2 protein activity may play a role in the interaction between the host and the microbiome.
Deficiency of ACSS2 protein activity in macrophages has been shown to impair phagocytosis and reduce the production of inflammatory cytokines.
ACSS2 protein is involved in the regulation of fatty acid oxidation by providing the acetyl-CoA needed for entry into the TCA cycle.
Customer Reviews (5)
Write a reviewIt showed superior stability, retaining its activity even under challenging experimental conditions. It has significantly improved the reliability of our assays.
It's a game-changer for any lab seeking efficiency.
This protein is a rock star! It consistently delivers outstanding results with a smile.
The quality-price ratio of this protein is truly commendable.
Its reliable and reproducible results have facilitated precise data acquisition, supporting the validity and integrity of our experimental findings.
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