Recombinant Full Length Human ADAMTS12 Protein, GST-tagged

• Cat.No.: ADAMTS12-916HF
• Product Overview: Human ADAMTS12 full-length ORF ( AAH58841.1, 1 a.a. - 229 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 52.4 kDa
• Protein Length: 229 amino acids
• AA Sequence: MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP EYHVVGPVRV DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK DLFFNLTVNQ GFLSNSYIME KRYGNLSHVK MMASSAPLCH LSGTVLQQGT RVGTAALSAC HGLTGFFQLP HGDFFIEPVK KHPLVEGGYH PHIVYRRQKV PETKEPTCGL KGIVTHMSSW VEESVLFFW
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 [ Homo sapiens ]
• Official Symbol: ADAMTS12
• Synonyms: ADAMTS12; ADAM metallopeptidase with thrombospondin type 1 motif, 12; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS12; ADAMTS-12; ADAM-TS 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389
• Gene ID: 81792
• mRNA Refseq: NM_030955
• Protein Refseq: NP_112217
• MIM: 606184
• UniProt ID: P58397

Reviews

01/16/2023

I got this product at a discounted price, with some discounted prices. It also works well for ELISA.

05/05/2021

Fast shipping, quality product, right price, worth buying!

03/01/2021

Customer service patiently communicated with me and helped me to determine the experimental matters.

02/24/2021

The purchased ADAMTS12 protein is suitable for WB experiments and I am satisfied with the results.

Q&As

How long will it take to ship?

We will ship as soon as possible after your purchase.

Is ADAMTS12 involved in the mitogen activated protein kinases signaling pathway?

ADAMTS12 blocked the mitogen activated protein kinase signaling pathway and prevented the tumorigenic effect of hepatocyte growth factor.

What diseases is ADAMTS12 currently used in research?

ADAMTS12 is more frequently studied in pancreatic and liver cancers.

Can the labeling of the full-length protein be changed?

We can customize the production products according to your needs.

Is ADAMTS12 expressed in normal tissues?

Not expressed, ADAMTS12 protein is only widely expressed in malignant digestive system tumor tissues.

Does ADAMTS12 affect epithelial-mesenchymal transition(EMT)?

Yes, reducing the expression of ADAMTS12 interferes with the EMT process.

What are the biological functions of ADAMTS12?

ADAMTS12 has the capabilities of tissue remodeling and cell migration and may work during normal inflammatory response.

I want to buy ADAMTS12 for western blotting, can you recommend it?

You can contact our experts directly, and they will recommend suitable products for you according to your research purpose.