Recombinant Full Length Human AVEN Protein, GST-tagged

• Cat.No.: AVEN-1254HF
• Product Overview: Human AVEN full-length ORF ( NP_065104.1, 1 a.a. - 362 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: AVEN (Apoptosis And Caspase Activation Inhibitor) is a Protein Coding gene. Diseases associated with AVEN include Schizoid Personality Disorder and Alzheimer Disease Mitochondrial. Among its related pathways are Apoptosis and Autophagy.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 64.9 kDa
• Protein Length: 362 amino acids
• AA Sequence: MQAERGARGG RGRRPGRGRP GGDRHSERPG AAAAVARGGG GGGGGDGGGR RGRGRGRGFR GARGGRGGGG APRGSRREPG GWGAGASAPV EDDSDAETYG EENDEQGNYS KRKIVSNWDR YQDIEKEVNN ESGESQRGTD FSVLLSSAGD SFSQFRFAEE KEWDSEASCP KQNSAFYVDS ELLVRALQEL PLCLRLNVAA ELVQGTVPLE VPQVKPKRTD DGKGLGMQLK GPLGPGGRGP IFELKSVAAG CPVLLGKDNP SPGPSRDSQK PTSPLQSAGD HLEEELDLLL NLDAPIKEGD NILPDQTSQD LKSKEDGEVV QEEEVCAKPS VTEEKNMEPE QPSTSKNVTE EELEDWLDSM IS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AVEN apoptosis, caspase activation inhibitor [ Homo sapiens ]
• Official Symbol: AVEN
• Synonyms: AVEN; apoptosis, caspase activation inhibitor; cell death regulator Aven; cell death regulator aven; PDCD12; programmed cell death 12
• Gene ID: 57099
• mRNA Refseq: NM_020371
• Protein Refseq: NP_065104
• MIM: 605265
• UniProt ID: Q9NQS1

Reviews

03/22/2023

Endotoxin levels are low and do not interfere with the experimental results.

03/10/2021

AVEN is highly expressed and can be easily detected.

06/30/2020

It performs well in Western blots, even if stored for a long time, it will not affect its performance.

Q&As

What diseases are associated with AVEN?

AVEN has been implicated in the development of some cancers, particularly acute promyelocytic leukemia (APL). The high expression of AVEN is closely related to the pathogenesis of APL.

How do you regulate AVEN's activities?

The activity of AVEN can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the function of AVEN.

What are the potential applications of AVEN in cancer therapy?

Potential applications of AVEN in cancer therapy include therapeutic targets, diagnostic markers, and drug development candidates. Drug development for AVEN may help treat certain types of cancer.

Does AVEN inhibit apoptosis?

It can interact with other members of the Bcl-2 protein family to inhibit the activation of the mitochondrial apoptotic pathway by blocking the activation of the pro-apoptotic proteins Bax and Bak.

Does AVEN function differently in different cell types?

The role of AVEN in different types of cells may vary. Its function may be affected by factors such as cell type, tissue, and stage of development.

How is the expression level of AVEN regulated?

The expression level of AVEN is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the AVEN gene, thereby regulating its expression level in cells.