Recombinant Full Length Mouse Dnmt3a Protein, Flag-tagged
Cat.No. : | Dnmt3a-03MFL |
Product Overview : | Recombinant Full Length Mouse DNA methyltransferase 3A (Dnmt3a), fused with C-terminal Flag tag, was expressed in mamanlian cells. |
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Description : | This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. |
Source : | Mamanlian cells |
Species : | Mouse |
Tag : | Flag |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method. |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Dnmt3a DNA methyltransferase 3A [ Mus musculus (house mouse) ] |
Official Symbol : | Dnmt3a |
Synonyms : | Dnmt3a; DNA methyltransferase 3A; MmuIIIA; DNA (cytosine-5)-methyltransferase 3A; DNA MTase MmuIIIA; DNA methyltransferase MmuIIIA; cysteine methyltransferase DNMT3A; EC 2.1.1.37 |
Gene ID : | 13435 |
mRNA Refseq : | NM_007872 |
Protein Refseq : | NP_031898 |
UniProt ID : | O88508 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDNMT3A mutations can serve as biomarkers for certain cancers, aiding in the diagnosis and classification of hematologic malignancies.
DNMT3A is essential for normal DNA methylation patterns during development and differentiation, influencing gene expression and cellular function.
Like many targeted therapies, DNMT3A-targeted treatments may have off-target effects, and their specificity is an area of active research.
Yes, molecular diagnostic tests, such as DNA sequencing, can identify DNMT3A mutations in cancer cells.
DNMT3A mutations lead to abnormal DNA methylation patterns, contributing to altered gene expression and promoting cancer development.
Customer Reviews (3)
Write a reviewIts exceptional characteristics, coupled with the manufacturer's commitment to customer satisfaction, ensure that I can pursue my scientific investigations with confidence and success.
Its consistent performance and reproducibility have been praised by scientists who have employed it in their studies, with many reporting outstanding results and a high level of satisfaction.
This level of support becomes invaluable, allowing researchers to focus on their scientific objectives while receiving expert guidance alongside.
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