Recombinant Full Length Phaeosphaeria Nodorum Dol-P-Man:Man(5)Glcnac(2)-Pp-Dol Alpha-1,3-Mannosyltransferase(Alg3) Protein, His-Tagged
Cat.No. : | RFL17072PF |
Product Overview : | Recombinant Full Length Phaeosphaeria nodorum Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase(ALG3) Protein (Q0TVF9) (1-609aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-609) |
AA Sequence : | MSKLSPALKQLINAAHSRPGPVPAP PRIQAVYQRIQEEATERKLGRPSWL GISTAATMTM NSPESMIALYNSTSASRPENESVQI AEFMREIGLKCIGFNGIPRTINMLN AFRASLPPTI ASSLNTTPTRSPSPQNILDTNTRGR ALWDAIYRPLETKLIDKLGDAHPDL PVFIINQEYG GLFTDPPGKPGAKVGRVTTSLVAIT CLRAQQGVGPQVLSHVFGLRKGWED GTWKEEPEAG SEEAIRWLVSDEGCTWVLEKVDELV EALGGGAGTLSPAIDEKPKELTTTK TMSLINRVRD LATNDEHTRWMIPLLLVVDAALCGV VIEKIPYTEIDWTTYMQHIALIIKG ERDYTKITGS TGPLVYPGAHVWIYKQLFKITDEGR DIQRAQYIFALVYLGTLALVFQCYR KARVPPYVFP LLILSKRLHSIFLLRCFNDCFAVLG LFAALFCYQRDQWHVGSFLFATGLN VKMSLLLPLP AMGVLMIMKLGSREAMTHAMIIFQT TVLFGYPFRKAAFSYFGRAFELSRQ FTYKWTVNWR FVSEETFLSKPFALGLLSVHVTLLI TFFLTRWIKPSKRTPKQFLKIIMPQ AEPRDQDTMA LRITPNLHT |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | ALG3 |
Synonyms : | ALG3; SNOG_16505; Dol-P-Man:Man(5GlcNAc(2-PP-Dol alpha-1,3-mannosyltransferase; Asparagine-linked glycosylation protein 6; Dol-P-Man-dependent alpha(1-3-mannosyltransferase; Dolichyl-P-Man:Man(5GlcNAc(2-PP-dolichyl mannosyltransferase |
UniProt ID : | Q0TVF9 |
Gene Name : | ALG3 |
Synonyms : | ALG3; SNOG_16505; Dol-P-Man:Man(5GlcNAc(2-PP-Dol alpha-1,3-mannosyltransferase; Asparagine-linked glycosylation protein 6; Dol-P-Man-dependent alpha(1-3-mannosyltransferase; Dolichyl-P-Man:Man(5GlcNAc(2-PP-dolichyl mannosyltransferase |
UniProt ID : | Q0TVF9 |
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Q&As (18)
Ask a questionThis protein plays an important role in some neurological diseases, such as central nervous system dysplasia, leading to symptoms such as mental retardation and muscle weakness.
No studies have confirmed whether ALG3 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.
ALG3 catalyzes the sugar chain transfer reaction between UDP-glucose and substrate proteins, synthesizing sugar chains onto proteins.
At present, there is no direct evidence that ALG3 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.
The selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.
The mutation may be associated with some genetic diseases, such as CDG (Congenital Disorder of Glycosylation).
ALG3 mutation may lead to the occurrence and development of some metabolic diseases such as CDG, and further investigation is needed to confirm its role in metabolic diseases.
This protein interacts with members of the glycosylase family such as ALG2, ALG1 and other related proteins to jointly regulate the glycosylation process of proteins.
ALG3 is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.
ALG3 is involved in metabolic pathways such as glycosylation and glucose metabolism.
ALG3 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.
Although there are currently no studies demonstrating the function of ALG3 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.
ALG3 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.
Overexpression or knockout of ALG3 can negatively affect the glycosylation of cells and the stability of ER and Golgi bodies, but the specific effects need to be further explored.
A number of inhibitors have been developed that target ALG3 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.
This protein mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.
The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG2 and ALG1.
ALG3 gene contains 12 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.
Customer Reviews (4)
Write a reviewALG3 has inhibitory or killing effects on specific pathogens.
This protein was found to have high sensitivity and specificity in biosensor preparation.
In drug screening experiments, ALG3 was found to have good selectivity for specific disease-related targets.
ALG3 can promote cell growth and proliferation in cell culture experiments.
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