Recombinant Human ACP2, His-tagged
Cat.No. : | ACP2-9307H |
Product Overview : | Recombinant Human ACP2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 37-383a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | ACP2 acid phosphatase 2, lysosomal [ Homo sapiens ] |
Official Symbol : | ACP2 |
Synonyms : | ACP2; acid phosphatase 2, lysosomal; lysosomal acid phosphatase; LAP; |
Gene ID : | 53 |
mRNA Refseq : | NM_001131064 |
Protein Refseq : | NP_001124536 |
MIM : | 171650 |
UniProt ID : | P11117 |
Chromosome Location : | 11p11.2 |
Pathway : | Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Riboflavin metabolism, organism-specific biosystem; Riboflavin metabolism, conserved biosystem; |
Function : | acid phosphatase activity; hydrolase activity; phosphoprotein phosphatase activity; phosphotyrosine binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a question100 mM NaCL, 20 mM Hepes, 10% glycerol. pH value is at the discretion of the manufacturer.
The high expression of ACP2 in CRC patients was associated with increased sensitivity to 5-FU chemotherapy.
The membrane-bound form is converted to the soluble form by sequential proteolytic processing; First, the C-terminal cytoplasmic tail is removed; Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.
Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures.
Among patients who received chemotherapy, those with an high expression of ACP2 showed better survival in both stage II and III colorectal cancer than those with low ACP2 expression.
D-Phenylalanine - Approved, Experimental, Investigational. D-Tyrosine - Approved, Experimental, Investigational.
ACP2 protein solution (1mg/ml) contains 20mM Tris-HCl (pH8.0) and 10% glycerol.
Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
They are TRHR, GMDS, SGCA, FPGS, and BAZ1B
Customer Reviews (5)
Write a reviewHighly recommended!
Great performance in ELISA.
Excellent, we will definitely go back to buy this again!
Fast delivery !
Satisfied with five starts!
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