Recombinant Human ACP2 Protein, GST-Tagged
Cat.No. : | ACP2-179H |
Product Overview : | Human ACP2 full-length ORF ( AAH03160, 1 a.a. - 423 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 72.27 kDa |
AA Sequence : | MAGKRSGWSRAALLQLLLGVNLVVM PPTQARSLRFVTLLYRHGDRSPVKT YPKDPYQEEEWPQGFGQLTKEGMLQ HWELGQALRQRYHGFLNTSYHRQEV YVRSTDFDRTLMSAEANLAGLFPPN GMQRFNPNISWQPIPVHTVPITEDR LLKFPLGPCPRYEQLQNETRQTPEY QNESSRNAQFLDMVANETGLTDLTL ETVWNVYDTLFCEQTHGLRLPPWAS PQTMQRLSRLKDFSFRFLFGIYQQA EKARLQGGVLLAQIRKNLTLMATTS QLPKLLVYSAHDTTLVALQMALDVY NGEQAPYASCHIFELYQEDSGNFSV EMYFRNESDKAPWPLSLPGCPHRCP LQDFLRLTEPVVPKDWQQECQLASG PADTEVIVALAVCGSILFLLIVLLL TVLFRMQAQPPGYRHVADGEDHA |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ACP2 acid phosphatase 2, lysosomal [ Homo sapiens ] |
Official Symbol : | ACP2 |
Synonyms : | ACP2; acid phosphatase 2, lysosomal; lysosomal acid phosphatase; LAP; |
Gene ID : | 53 |
mRNA Refseq : | NM_001131064 |
Protein Refseq : | NP_001124536 |
MIM : | 171650 |
UniProt ID : | P11117 |
Products Types
◆ Recombinant Protein | ||
ACP2-46H | Recombinant Human ACP2 Protein, His-tagged | +Inquiry |
Acp2-515M | Recombinant Mouse Acp2 Protein, MYC/DDK-tagged | +Inquiry |
ACP2-2124Z | Recombinant Zebrafish ACP2 | +Inquiry |
ACP2-9307H | Recombinant Human ACP2, His-tagged | +Inquiry |
ACP2-3192C | Recombinant Chicken ACP2 | +Inquiry |
◆ Lysates | ||
ACP2-9082HCL | Recombinant Human ACP2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a question100 mM NaCL, 20 mM Hepes, 10% glycerol. pH value is at the discretion of the manufacturer.
The high expression of ACP2 in CRC patients was associated with increased sensitivity to 5-FU chemotherapy.
The membrane-bound form is converted to the soluble form by sequential proteolytic processing; First, the C-terminal cytoplasmic tail is removed; Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.
Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures.
Among patients who received chemotherapy, those with an high expression of ACP2 showed better survival in both stage II and III colorectal cancer than those with low ACP2 expression.
D-Phenylalanine - Approved, Experimental, Investigational. D-Tyrosine - Approved, Experimental, Investigational.
ACP2 protein solution (1mg/ml) contains 20mM Tris-HCl (pH8.0) and 10% glycerol.
Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
They are TRHR, GMDS, SGCA, FPGS, and BAZ1B
Customer Reviews (5)
Write a reviewHighly recommended!
Great performance in ELISA.
Excellent, we will definitely go back to buy this again!
Fast delivery !
Satisfied with five starts!
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