Recombinant Human ACP2 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | ACP2-2666H |
Product Overview : | ACP2 MS Standard C13 and N15-labeled recombinant protein (NP_001601) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 44.45 kDa |
AA Sequence : | MAGKRXXGWSRAALLQLLLGVNLVV MPPTRARSLRFVTLLYRHGDRSPVK TYPKDPYQEEEWPQGFGQLTKEGML QHWELGQALRQRYHGFLNTSYHRQE VYVRSTDFDRTLMSAEANLAGLFPP NGMQRFNPNISWQPIPVHTVPITED RLLKFPLGPCPRYEQLQNETRQTPE YQNESSRNAQFLDMVANETGLTDLT LETVWNVYDTLFCEQTHGLRLPPWA SPQTMQRLSRLKDFSFRFLFGIYQQ AEKARLQGGVLLAQIRKNLTLMATT SQLPKLLVYSAHDTTLVALQMALDV YNGEQAPYASCHIFELYQEDSGNFS VEMYFRNESDKAPWPLSLPGCPHRC PLQDFLRLTEPVVPKDWQQECQLAS GPADTEVIVALAVCGSILFLLIVLL LTVLFRMQAQPPGYRHVADGEDHAT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | ACP2 acid phosphatase 2, lysosomal [ Homo sapiens (human) ] |
Official Symbol : | ACP2 |
Synonyms : | ACP2; acid phosphatase 2, lysosomal; lysosomal acid phosphatase; LAP; |
Gene ID : | 53 |
mRNA Refseq : | NM_001610 |
Protein Refseq : | NP_001601 |
MIM : | 171650 |
UniProt ID : | P11117 |
Products Types
◆ Recombinant Protein | ||
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ACP2-46H | Recombinant Human ACP2 Protein, His-tagged | +Inquiry |
ACP2-2124Z | Recombinant Zebrafish ACP2 | +Inquiry |
ACP2-3192C | Recombinant Chicken ACP2 | +Inquiry |
ACP2-179H | Recombinant Human ACP2 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
ACP2-9082HCL | Recombinant Human ACP2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a question100 mM NaCL, 20 mM Hepes, 10% glycerol. pH value is at the discretion of the manufacturer.
The high expression of ACP2 in CRC patients was associated with increased sensitivity to 5-FU chemotherapy.
The membrane-bound form is converted to the soluble form by sequential proteolytic processing; First, the C-terminal cytoplasmic tail is removed; Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.
Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures.
Among patients who received chemotherapy, those with an high expression of ACP2 showed better survival in both stage II and III colorectal cancer than those with low ACP2 expression.
D-Phenylalanine - Approved, Experimental, Investigational. D-Tyrosine - Approved, Experimental, Investigational.
ACP2 protein solution (1mg/ml) contains 20mM Tris-HCl (pH8.0) and 10% glycerol.
Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
They are TRHR, GMDS, SGCA, FPGS, and BAZ1B
Customer Reviews (5)
Write a reviewHighly recommended!
Great performance in ELISA.
Excellent, we will definitely go back to buy this again!
Fast delivery !
Satisfied with five starts!
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