Recombinant Human ADAMTS10 Protein

• Cat.No.: ADAMTS10-297H
• Product Overview: Human ADAMTS10 (NP_001101.1, 214 a.a. - 672 a.a.) partial recombinant protein expressed in Escherichia coli.

Specification

• Description: This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
• Source: E. coli
• Species: Human
• Form: Liquid
• AA Sequence: TTSAEKNTCQLYIQTDHLFFKYYGT REAVIAQISSHVKAIDTIYQTTDFS GIRNISFMVKRIRINTTADEKDPTN PFRFPNIGVEKFLELNSEQNHDDYC LAYVFTDRDFDDGVLGLAWVGAPSG SSGGICEKSKLYSDGKKKSLNTGII TVQNYGSHVPPKVSHITFAHEVGHN FGSPHDSGTECTPGESKNLGQKENG NYIMYARATSGDKLNNNKFSLCSIR NISQVLEKKRNNCFVESGQPICGNG MVEQGEECDCGYSDQCKDECCFDAN QPEGRKCKLKPGKQCSPSQGPCCTA QCAFKSKSEKCRDDSDCAREGICNG FTALCPASDPKPNFTDCNRHTQVCI NGQCAGSICEKYGLEECTCASSDGK DDKELCHVCCMKKMDPSTCASTGSV QWSRHFSGRTITLQPGSPCNDFRGY CDVFMRCRLVDADGPLARLKKAIFS PELYENIAE
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Store at -20 centigrade. For long term storage store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: In PBS (50% glycerol)

Gene Information

• Gene Name: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 [ Homo sapiens ]
• Official Symbol: ADAMTS10
• Synonyms: ADAMTS10; ADAM metallopeptidase with thrombospondin type 1 motif, 10; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; A disintegrin and metalloproteinase with thrombospondin motifs 10; ADAM TS10; ADAMTS-10; ADAM-TS 10; zinc metalloendopeptidase; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; WMS; WMS1; ADAM-TS10
• Gene ID: 81794
• mRNA Refseq: NM_030957
• Protein Refseq: NP_112219
• MIM: 608990
• UniProt ID: Q9H324

Reviews

03/04/2021

Prompt dispatch and smooth delivery helped me to obtain satisfactory experimental results within a short period of time

06/30/2020

The ADAMTS10 protein purchased was suitable for WB experiments and the experiments went very well and satisfactory results were obtained

05/08/2019

The delivery is very fast, the protein activity is good, and it can show good experimental results.

Q&As

What are the applications of ADAMTS10 in the study of diseases?

ADAMTS10 is mainly involved in the study ofpancreatic cancer, breast cancer and lung cancer.

Does ADAMTS10 interact with fibrillin-1?

Yes, they interact with each other and are co-located in human skin.

Can ADAMTS10-1308M specify the product form?

Yes, we can ship according to the product form you specify.

Where is ADAMTS10 mainly expressed?

ADAMTS10 is mainly expressed in the lung, kidney and bone.

Does this promotion apply to all protein products and custom needs?

Yes, this promotion applies to all protein products and custom needs.

Is human ADAMTS10 protein in stock?

Human ADAMTS10 protein is in stock.

What proteins does ADAM10 cleave?

ADAM10 cleaves transmembrane proteins such as amyloid precursor protein, E-calmodulin, N-calmodulin and NOTCH.

Can the tag of Zebrafish ADAMTS10 be other than His?

We can customize the tag according to your requirements.

What happens when ADAM10 is highly expressed?

High expression of ADAM10 leads to Notch signal pathway activation and stimulation of VSMCs proliferation.

Do you offer other expression systems for ADAMTS10 protein expression?

We provide several different protein expression systems, including baculovirus-insect cell expression systems, cell-free in vitro protein expression systems, yeast expression systems, etc.