Recombinant Human ADAMTS10 protein, His & T7-tagged

• Cat.No.: ADAMTS10-1759H
• Product Overview: Recombinant Human ADAMTS10 aa. (Arg239~Pro602 (Accession # Q9H324)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
• Source: E. coli
• Species: Human
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 43.7kDa
• Protein length: Arg239~Pro602 (Accession # Q9H324)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 7.8

Gene Information

• Gene Name: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 [ Homo sapiens (human) ]
• Official Symbol: ADAMTS10
• Synonyms: ADAMTS10; ADAM metallopeptidase with thrombospondin type 1 motif 10; WMS; WMS1; ADAM-TS10; ADAMTS-10; A disintegrin and metalloproteinase with thrombospondin motifs 10; ADAM-TS 10; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; zinc metalloendopeptidase
• Gene ID: 81794
• mRNA Refseq: NM_001282352.1
• Protein Refseq: NP_001269281.1
• UniProt ID: Q9H324

Reviews

03/04/2021

Prompt dispatch and smooth delivery helped me to obtain satisfactory experimental results within a short period of time

06/30/2020

The ADAMTS10 protein purchased was suitable for WB experiments and the experiments went very well and satisfactory results were obtained

05/08/2019

The delivery is very fast, the protein activity is good, and it can show good experimental results.

Q&As

What are the applications of ADAMTS10 in the study of diseases?

ADAMTS10 is mainly involved in the study ofpancreatic cancer, breast cancer and lung cancer.

Does ADAMTS10 interact with fibrillin-1?

Yes, they interact with each other and are co-located in human skin.

Can ADAMTS10-1308M specify the product form?

Yes, we can ship according to the product form you specify.

Where is ADAMTS10 mainly expressed?

ADAMTS10 is mainly expressed in the lung, kidney and bone.

Does this promotion apply to all protein products and custom needs?

Yes, this promotion applies to all protein products and custom needs.

Is human ADAMTS10 protein in stock?

Human ADAMTS10 protein is in stock.

What proteins does ADAM10 cleave?

ADAM10 cleaves transmembrane proteins such as amyloid precursor protein, E-calmodulin, N-calmodulin and NOTCH.

Can the tag of Zebrafish ADAMTS10 be other than His?

We can customize the tag according to your requirements.

What happens when ADAM10 is highly expressed?

High expression of ADAM10 leads to Notch signal pathway activation and stimulation of VSMCs proliferation.

Do you offer other expression systems for ADAMTS10 protein expression?

We provide several different protein expression systems, including baculovirus-insect cell expression systems, cell-free in vitro protein expression systems, yeast expression systems, etc.