Recombinant Human ADCK5, GST-tagged
Cat.No. : | ADCK5-98H |
Product Overview : | Recombinant human ADCK5 (68-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Description : | ADCK5 belongs to the protein kinase superfamily, ADCK protein kinase family that contains a protein kinase domain. The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrates it would phosphorylate. An important paralog of this gene is ADCK1. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~83 kDa |
Purity : | >75% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05 ug/ul |
Gene Name : | ADCK5 aarF domain containing kinase 5 [ Homo sapiens ] |
Official Symbol : | ADCK5 |
Synonyms : | ADCK5; aarF domain containing kinase 5; uncharacterized aarF domain-containing protein kinase 5; FLJ35454; MGC126708; |
Gene ID : | 203054 |
mRNA Refseq : | NM_174922 |
Protein Refseq : | NP_777582 |
UniProt ID : | Q3MIX3 |
Chromosome Location : | 8q24.3 |
Function : | kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
ADCK5-326H | Recombinant Human ADCK5 Protein, GST-tagged | +Inquiry |
ADCK5-7997Z | Recombinant Zebrafish ADCK5 | +Inquiry |
ADCK5-9407H | Recombinant Human ADCK5, His-tagged | +Inquiry |
◆ Lysates | ||
ADCK5-11HCL | Recombinant Human ADCK5 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionADCK5 protein may be a target for drug development aimed at improving CoQ10 biosynthesis and mitochondrial function. However, more research is needed to fully understand the role of ADCK5 protein in these processes and to identify potential drug targets.
ADCK5 protein has been shown to play a critical role in CoQ10 biosynthesis, which is important for energy production and mitochondrial function. Therapeutic applications of ADCK5 protein may include the treatment of conditions related to CoQ10 deficiency or mitochondrial dysfunction, such as neurodegenerative diseases, muscle disorders, and heart disease.
There is currently no evidence to suggest that ADCK5 protein supplementation can improve athletic performance. While CoQ10 supplements may be helpful in some cases of mitochondrial dysfunction, their effects on athletic performance have not been well-established.
While ADCK5 protein plays a role in cellular energy production and mitochondrial function, there is no evidence to suggest that ADCK5 protein supplementation can improve cognitive function. However, CoQ10 supplements have been studied for their potential benefits for cognitive function and neurological disorders, and further research is needed to understand the potential role of ADCK5 protein in these conditions.
ADCK5 protein is being studied in various research settings to better understand its role in CoQ10 biosynthesis and mitochondrial function. This includes studies using cell-based models, animal models, and genetic analyses of patients with mitochondrial disorders or CoQ10 deficiency. Researchers are also exploring the potential therapeutic effects of ADCK5 protein and CoQ10 supplementation on various conditions.
While ADCK5 protein is involved in the pathogenesis of PHSP, it is not yet clear whether it can be used as a therapeutic target for the treatment of this condition. However, research is ongoing to explore the potential use of ADCK5 and CoQ10 biosynthesis pathway for the treatment of PHSP.
ADCK5 protein is expressed in many tissues throughout the body, but it is primarily found in tissues with high energy demands, such as the heart, liver, and skeletal muscles. It is also expressed in the brain and nervous system, indicating its potential role in neurological functions.
At present, there is insufficient evidence to support the use of ADCK5 protein as a biomarker for disease diagnosis or prognosis. However, further research may reveal its potential utility as a biomarker for certain conditions, particularly those that involve mitochondrial dysfunction.
Yes, mutations in the ADCK5 gene have been associated with a rare form of progressive hereditary spastic paralysis (PHSP), which is a neurological disorder that affects the spinal cord and causes muscle weakness and stiffness.
Currently, there are no clinical trials for ADCK5 protein therapy, but research is ongoing to explore the potential therapeutic applications of ADCK5 protein or the CoQ10 biosynthesis pathway. It is possible that clinical trials may be developed in the future, particularly for diseases that involve mitochondrial dysfunction.
ADCK5 protein activity is regulated by various factors, including the availability of its substrate (p-aminobenzoate), as well as other enzymes and cofactors involved in the CoQ10 biosynthesis pathway. Additionally, ADCK5 can be phosphorylated, which can affect its enzymatic activity and stability.
Currently, there are no clinical trials specifically focused on ADCK5 protein. However, some clinical trials are investigating the potential therapeutic effects of CoQ10 supplements on various conditions, including Parkinson's disease, heart failure, and muscular dystrophy.
There is currently no evidence to suggest that ADCK5 protein supplementation can improve mitochondrial function. CoQ10 supplements have been studied for their potential benefits for mitochondrial function and energy metabolism, but the effects of ADCK5 protein supplementation are not yet understood.
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