Recombinant Human ARMCX2, GST-tagged

• Cat.No.: ARMCX2-9872H
• Product Overview: Recombinant Human ARMCX2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX1 and ALEX3, on the X chromosome. Two alternative transcripts that encode the same protein but differ in the 5 UTR have been described. Additional alternative transcripts may exist but their full length natures have not been determined. A pseudogene for this locus is located on chromosome 7.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-300a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ARMCX2 armadillo repeat containing, X-linked 2 [ Homo sapiens ]
• Official Symbol: ARMCX2
• Synonyms: armadillo repeat containing, X-linked 2; arm protein lost in epithelial cancers, X chromosome, 2; ALEX2; armadillo repeat protein ALEX2; KIAA0512; armadillo repeat-containing X-linked protein 2; ARM protein lost in epithelial cancers on chromosome X 2; Protein ALEX2
• Gene ID: 9823
• mRNA Refseq: NM_014782.5
• Protein Refseq: NP_055597.1
• MIM: 300363
• UniProt ID: Q7L311
• Chromosome Location: Xq21.33-q22.2

Reviews

11/14/2022

Their knowledgeable and responsive team stands ready to address any concerns or challenges I may encounter.

07/01/2020

To further elevate my confidence, the manufacturer's commitment to offering exemplary technical support is truly commendable.

04/03/2018

Its purity, stability, and functional integrity are of the highest standard, instilling confidence in generating accurate and insightful results crucial for my research objectives.

05/06/2017

The use of ARMCX2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.

02/09/2017

ARMCX2 protein has shown great utility in protein electron microscopy structure analysis.

05/26/2016

It enables accurate detection and quantification of ARMCX2 protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

Q&As

Can changes in ARMCX2 expression levels affect neuronal development or function?

The specific impact of changes in ARMCX2 expression levels on neuronal development or function is not yet clearly understood. Further research is necessary to explore the potential roles of ARMCX2 in these processes.

Are there any animal models available for studying the function of ARMCX2?

There are currently no specific animal models available for studying the function of ARMCX2. Generating animal models, such as knockout mice, could be useful for investigating its biological roles in vivo.

Where is the ARMCX2 protein predominantly expressed?

The ARMCX2 protein is mainly expressed in the brain, particularly in regions such as the cerebral cortex, hippocampus, and cerebellum. It has also been detected in other tissues to a lesser extent, including the heart, kidney, and testis.

Does the ARMCX2 protein have any known interacting partners?

Currently, there is limited information available regarding known interacting partners of the ARMCX2 protein. Identifying and characterizing its protein-protein interactions is an area of ongoing research.

Is the expression of the ARMCX2 gene tissue-specific?

Yes, the expression of the ARMCX2 gene is tissue-specific, with the highest expression levels observed in the brain. However, low levels of ARMCX2 expression have been reported in other tissues as well.