Recombinant Human ARSD Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ARSD-1748H
• Product Overview: ARSD MS Standard C13 and N15-labeled recombinant protein (NP_001660) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 64.86 kDa
• AA Sequence: MRSAARRGRAAPAARDSLPVLLFLC LLLKTCEPKTANAFKPNILLIMADD LGTGDLGCYGNNTLRTPNIDQLAEE GVRLTQHLAAAPLCTPSRAAFLTGR HSFRSGMDASNGYRALQWNAGSGGL PENETTFARILQQHGYATGLIGKWH QGVNCASRGDHCHHPLNHGFDYFYG MPFTLTNDCDPGRPPEVDAALRAQL WGYTQFLALGILTLAAGQTCGFFSV SARAVTGMAGVGCLFFISWYSSFGF VRRWNCILMRNHDVTEQPMVLEKTA SLMLKEAVSYIERHKHGPFLLFLSL LHVHIPLVTTSAFLGKSQHGLYGDN VEEMDWLIGKVLNAIEDNGLKNSTF TYFTSDHGGHLEARDGHSQLGGWNG IYKGGKGMGGWEGGIRVPGIFHWPG VLPAGRVIGEPTSLMDVFPTVVQLV GGEVPQDRVIDGHSLVPLLQGAEAR SAHEFLFHYCGQHLHAARWHQKDSG SVWKVHYTTPQFHPEGAGACYGRGV CPCSGEGVTHHRPPLLFDLSRDPSE ARPLTPDSEPLYHAVIARVGAAVSE HRQTLSPVPQQFSMSNILWKPWLQP CCGHFPFCSCHEDGDGTPTRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ARSD arylsulfatase D [ Homo sapiens (human) ]
• Official Symbol: ARSD
• Synonyms: ARSD; arylsulfatase D; ASD; arylsulfatase D; testis tissue sperm-binding protein Li 39a; EC 3.1.6.1
• Gene ID: 414
• mRNA Refseq: NM_001669
• Protein Refseq: NP_001660
• MIM: 300002
• UniProt ID: P51689

Reviews

04/18/2020

The impressive performance of the ARSD protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.

11/01/2017

the ARSD protein finds extensive utility in protein electron microscopy structure analysis.

02/25/2016

Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.

Q&As

Is the ARSD protein involved in any specific biological pathways or processes?

While the precise role of ARSD in specific biological pathways is still under investigation, it is known to participate in the breakdown of sulfated molecules within lysosomes, contributing to normal cellular metabolism and recycling of molecules.

Are there any known inhibitors or activators of the ARSD protein?

Currently, there are no specific inhibitors or activators that have been developed for the ARSD protein. However, general inhibitors or activators of sulfatase enzymes might have an effect on ARSD activity.

What are the potential consequences of impaired ARSD activity?

If the activity of ARSD is impaired, it can lead to the accumulation of sulfated molecules within lysosomes. This can disrupt normal cellular processes and potentially contribute to lysosomal storage disorders or other related disorders.

Are there any known genetic disorders associated with mutations in the ARSD gene?

Currently, there are no known genetic disorders specifically associated with mutations in the ARSD gene. However, mutations in related sulfatase genes can lead to various lysosomal storage disorders, such as multiple sulfatase deficiency (MSD).

How is the ARSD protein regulated?

The regulation of ARSD protein activity is not well understood. However, like other lysosomal enzymes, its activity may be influenced by factors such as pH and post-translational modifications.