Recombinant Human ASCC1, GST-tagged

• Cat.No.: ASCC1-9922H
• Product Overview: Recombinant Human ASCC1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: N-term-355a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ASCC1 activating signal cointegrator 1 complex subunit 1 [ Homo sapiens ]
• Official Symbol: ASCC1
• Synonyms: ASCC1; activating signal cointegrator 1 complex subunit 1; ASC1p50; CGI 18; Em:AC022392.3; ASC-1 complex subunit P50; trip4 complex subunit p50; p50; CGI-18
• Gene ID: 51008
• mRNA Refseq: NM_001198798
• Protein Refseq: NP_001185727
• MIM: 614215
• UniProt ID: Q8N9N2
• Chromosome Location: 10pter-q25.3
• Function: RNA binding

Reviews

11/25/2022

the use of ASCC1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

05/24/2018

The manufacturer's support and expertise further enhance the utility of ASCC1 in my experimental work, ensuring reliable and high-quality results.

11/13/2017

This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

Q&As

How is ASCC1 localization regulated within the cell?

ASCC1 is primarily localized in the nucleus of cells, where it functions in gene expression regulation. It is believed to shuttle between the nucleus and cytoplasm upon specific cellular signaling events.

Does ASCC1 have any post-translational modifications?

The post-translational modifications of ASCC1 have not been extensively studied. However, it is possible that ASCC1 undergoes modifications such as phosphorylation or acetylation, which can regulate its function.

Does ASCC1 have any role in DNA repair processes?

Yes, ASCC1 is involved in DNA repair processes as part of the ASC-1 complex. It participates in the repair of DNA double-strand breaks, contributing to genome stability.

In which tissues or cell types is ASCC1 expressed?

ASCC1 is expressed in a wide range of tissues and cell types, including but not limited to the brain, liver, heart, and skeletal muscle.

Is there any association between ASCC1 and human diseases?

Currently, there are no known human diseases directly associated with ASCC1. However, dysregulation of transcriptional coactivation complexes, in which ASCC1 is involved, can contribute to various diseases.

Can ASCC1 be targeted for therapeutic interventions or drug discovery?

Given the limited understanding of ASCC1's specific role in diseases, it is currently uncertain if it can be directly targeted for therapeutic interventions or drug discovery.

What are the known interacting partners of ASCC1?

ASCC1 interacts with various proteins and transcription factors, such as ATF2, TAF12, and TRIM28, to form the ASC-1 complex and regulate gene expression.