Recombinant Human ATP2A2 protein, GST-tagged

• Cat.No.: ATP2A2-970H
• Product Overview: Human ATP2A2 full-length ORF ( NP_001672.1, 1 a.a. - 997 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 136.1 kDa
• AA Sequence: MENAHTKTVEEVLGHFGVNESTGLS LEQVKKLKERWGSNELPAEEGKTLL ELVIEQFEDLLVRILLLAACISFVL AWFEEGEETITAFVEPFVILLILVA NAIVGVWQERNAENAIEALKEYEPE MGKVYRQDRKSVQRIKAKDIVPGDI VEIAVGDKVPADIRLTSIKSTTLRV DQSILTGESVSVIKHTDPVPDPRAV NQDKKNMLFSGTNIAAGKAMGVVVA TGVNTEIGKIRDEMVATEQERTPLQ QKLDEFGEQLSKVISLICIAVWIIN IGHFNDPVHGGSWIRGAIYYFKIAV ALAVAAIPEGLPAVITTCLALGTRR MAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFILDRVEGD TCSLNEFTITGSTYAPIGEVHKDDK PVNCHQYDGLVELATICALCNDSAL DYNEAKGVYEKVGEATETALTCLVE KMNVFDTELKGLSKIERANACNSVI KQLMKKEFTLEFSRDRKSMSVYCTP NKPSRTSMSKMFVKGAPEGVIDRCT HIRVGSTKVPMTSGVKQKIMSVIRE WGSGSDTLRCLALATHDNPLRREEM HLEDSANFIKYETNLTFVGCVGMLD PPRIEVASSVKLCRQAGIRVIMITG DNKGTAVAICRRIGIFGQDEDVTSK AFTGREFDELNPSAQRDACLNARCF ARVEPSHKSKIVEFLQSFDEITAMT GDGVNDAPALKKAEIGIAMGSGTAV AKTASEMVLADDNFSTIVAAVEEGR AIYNNMKQFIRYLISSNVGEVVCIF LTAALGFPEALIPVQLLWVNLVTDG LPATALGFNPPDLDIMNKPPRNPKE PLISGWLFFRYLAIGCYVGAATVGA AAWWFIAADGGPRVSFYQLSHFLQC KEDNPDFEGVDCAIFESPYPMTMAL SVLVTIEMCNALNSLSENQSLLRMP PWENIWLVGSICLSMSLHFLILYVE PLPLIFQITPLNVTQWLMVLKISLP VILMDETLKFVARNYLEPAILE
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Homo sapiens (human) ]
• Official Symbol: ATP2A2
• Synonyms: ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; DD; DAR; ATP2B; SERCA2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; SR Ca(2+)-ATPase 2
  calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; EC 3.6.3.8
• Gene ID: 488
• mRNA Refseq: NM_001681
• Protein Refseq: NP_001672
• MIM: 108740
• UniProt ID: P16615

Reviews

08/09/2020

Because ATP2A2 has a short half-life and high clearance, it better prevents drug accumulation in the body, thereby reducing the risk of side effects caused by long-term use.

07/28/2019

The production process of ATP2A2 focuses on harmonious coexistence with nature, realizes zero pollution in the production process, and brings a positive impact on the environment.

03/25/2019

It can maintain stable performance even in extremely harsh environments, which is a rare quality.

Q&As

Are ATP2A2 recombinant protein mutations associated with human nervous system related diseases?

Mutations in the recombinant ATP2A2 protein are associated with several nervous system related diseases, such as neurodegenerative diseases and neurodysregulation.

What are the structural features of the recombinant ATP2A2 protein?

ATP2A2 protein is a calcium pump protein containing multiple membrane channels and ATP-binding sites for the regulation of intracellular calcium homeostasis.

Is the expression and function of recombinant ATP2A2 protein regulated in the nervous system?

Yes, the expression and function of ATP2A2 recombinant protein in the nervous system are regulated by complex mechanisms, including endogenous signaling pathways and cell-to-cell interactions.

Is there any polymorphic variation or mutation in ATP2A2 recombinant protein?

Yes, there are polymorphic variations or mutations in ATP2A2 recombinant protein, which may be related to the susceptibility and pathogenesis of nervous system related diseases.

What is the function of ATP2A2 recombinant protein in the nervous system?

The recombinant ATP2A2 protein is responsible for regulating calcium homeostasis and maintaining nerve cell communication in the nervous system.

Does the recombinant ATP2A2 protein interact with other proteins?

The recombinant ATP2A2 protein interacts with other membrane proteins, such as calcium channels and transporters, to regulate the function of nerve cells.