Recombinant Human ATP5B Protein, His-tagged

• Cat.No.: ATP5B-1137H
• Product Overview: Recombinant Human ATP5B Protein (48-529aa) was expressed in yeast with N-terminal His-tag.

Specification

• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer, 50% glycerol.
• Molecular Mass: 53.8 kDa
• AA Sequence: AQTSPSPKAGAATGRIVAVIGAVVD VQFDEGLPPILNALEVQGRETRLVL EVAQHLGESTVRTIAMDGTEGLVRG QKVLDSGAPIKIPVGPETLGRIMNV IGEPIDERGPIKTKQFAPIHAEAPE FMEMSVEQEILVTGIKVVDLLAPYA KGGKIGLFGGAGVGKTVLIMELINN VAKAHGGYSVFAGVGERTREGNDLY HEMIESGVINLKDATSKVALVYGQM NEPPGARARVALTGLTVAEYFRDQE GQDVLLFIDNIFRFTQAGSEVSALL GRIPSAVGYQPTLATDMGTMQERIT TTKKGSITSVQAIYVPADDLTDPAP ATTFAHLDATTVLSRAIAELGIYPA VDPLDSTSRIMDPNIVGSEHYDVAR GVQKILQDYKSLQDIIAILGMDELS EEDKLTVSRARKIQRFLSQPFQVAE VFTGHMGKLVPLKETIKGFQQILAG EYDHLPEQAFYMVGPIEEAVAKADK LAEEHSS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: The shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.

Gene Information

• Gene Name: ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [ Homo sapiens ]
• Official Symbol: ATP5B
• Synonyms: ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; ATPSB; ATP synthase subunit beta, mitochondrial; mitochondrial ATP synthase beta subunit; mitochondrial ATP synthetase, beta subunit; ATPMB; MGC5231
• Gene ID: 506
• mRNA Refseq: NM_001686
• Protein Refseq: NP_001677
• MIM: 102910
• UniProt ID: P06576

Reviews

05/22/2020

The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.

04/25/2020

ATP5B has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.

04/07/2019

Because the production process is efficient and environmentally friendly, recombinant proteins can be produced on a large scale without negative environmental impacts.

Q&As

What is the frequency of ATP5B mutations?

ATP5B gene mutation frequency may be different in different diseases and populations, which needs further study.

How about the link between ATP5B protein and neurological diseases?

It plays an important role in the nervous system and is associated with certain nervous system diseases such as Parkinson's disease and cerebral ischemia.

How are ATP5B mutations associated with disease?

This gene mutations may lead to abnormal protein structure or function, which in turn affects the physiological function of the protein and is associated with specific diseases.

What are the regulatory mechanisms of ATP5B?

ATP5B expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.

How to evaluate the effect of ATP5B gene mutation on disease?

Assessment of the effect of ATP5B mutations on disease often requires a comprehensive analysis of gene sequencing, protein function studies, and clinical and epidemiological studies.

In which tissues or organs is ATP5B highly expressed?

It is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.