Recombinant Human AVEN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: AVEN-3208H
• Product Overview: AVEN MS Standard C13 and N15-labeled recombinant protein (NP_065104) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Protects against apoptosis mediated by Apaf-1.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 38.5 kDa
• AA Sequence: MQAERGARGGRGRRPGRGRPGGDRH SERPGAAAAVARGGGGGGGGDGGGR RGRGRGRGFRGARGGRGGGGAPRGS RREPGGWGAGASAPVEDDSDAETYG EENDEQGNYSKRKIVSNWDRYQDIE KEVNNESGESQRGTDFSVLLSSAGD SFSQFRFAEEKEWDSEASCPKQNSA FYVDSELLVRALQELPLCLRLNVAA ELVQGTVPLEVPQVKPKRTDDGKGL GMQLKGPLGPGGRGPIFELKSVAAG CPVLLGKDNPSPGPSRDSQKPTSPL QSAGDHLEEELDLLLNLDAPIKEGD NILPDQTSQDLKSKEDGEVVQEEEV CAKPSVTEEKNMEPEQPSTSKNVTE EELEDWLDSMISTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: AVEN apoptosis and caspase activation inhibitor [ Homo sapiens (human) ]
• Official Symbol: AVEN
• Synonyms: AVEN; apoptosis, caspase activation inhibitor; cell death regulator Aven; cell death regulator aven; PDCD12; programmed cell death 12
• Gene ID: 57099
• mRNA Refseq: NM_020371
• Protein Refseq: NP_065104
• MIM: 605265
• UniProt ID: Q9NQS1

Reviews

03/22/2023

Endotoxin levels are low and do not interfere with the experimental results.

03/10/2021

AVEN is highly expressed and can be easily detected.

06/30/2020

It performs well in Western blots, even if stored for a long time, it will not affect its performance.

Q&As

What diseases are associated with AVEN?

AVEN has been implicated in the development of some cancers, particularly acute promyelocytic leukemia (APL). The high expression of AVEN is closely related to the pathogenesis of APL.

How do you regulate AVEN's activities?

The activity of AVEN can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the function of AVEN.

What are the potential applications of AVEN in cancer therapy?

Potential applications of AVEN in cancer therapy include therapeutic targets, diagnostic markers, and drug development candidates. Drug development for AVEN may help treat certain types of cancer.

Does AVEN inhibit apoptosis?

It can interact with other members of the Bcl-2 protein family to inhibit the activation of the mitochondrial apoptotic pathway by blocking the activation of the pro-apoptotic proteins Bax and Bak.

Does AVEN function differently in different cell types?

The role of AVEN in different types of cells may vary. Its function may be affected by factors such as cell type, tissue, and stage of development.

How is the expression level of AVEN regulated?

The expression level of AVEN is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the AVEN gene, thereby regulating its expression level in cells.