Recombinant Human C1QB protein(Met1-Ala253), His-tagged
Cat.No. : | C1QB-596H |
Product Overview : | Recombinant Human C1QB (NP_000482.3)(Met 1-Ala 253) was expressed in Insect Cells, with a carboxy-terminal polyhistidine tag. |
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Source : | Insect Cells |
Species : | Human |
Tag : | C-His |
Protein length : | Met1-Ala253 |
Form : | Lyophilized from sterile 50mM Tris, 100mM NaCl, 10% Glycerol, 0.5mM TCEP, pH 7. 5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human C1QB consists of 237 amino acids with the predicted molecular mass of 25.2 kDa. As a result of glycosylation, rhC1QB migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 94 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | C1QB complement component 1, q subcomponent, B chain [ Homo sapiens ] |
Official Symbol : | C1QB |
Synonyms : | C1QB; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement C1q subcomponent subunit B; complement component C1q, B chain; complement subcomponent C1q chain B; |
Gene ID : | 713 |
mRNA Refseq : | NM_000491 |
Protein Refseq : | NP_000482 |
MIM : | 120570 |
UniProt ID : | P02746 |
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◆ Lysates | ||
C1QB-651HCL | Recombinant Human C1QB cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionC1QB, as part of C1q, plays a role in opsonization by marking pathogens and immune complexes for phagocytosis after binding and activating the complement system.
C1QB is one of the chains (together with C1QA and C1QC) that forms the C1q molecule, which is the first component of the classical pathway of the complement system, playing a crucial role in innate immunity.
Given the role of C1QB in the complement system and its association with autoimmune diseases, targeting C1QB or its interactions might be a therapeutic strategy for conditions like SLE or other complement-mediated diseases.
C1QB, as a part of the C1q molecule, plays a significant role in recognizing and binding to immune complexes, apoptotic cells, and certain pathogens, thereby activating the classical complement pathway and facilitating their clearance.
Once C1q (comprising C1QA, C1QB, and C1QC) binds to immune complexes, it triggers the binding and autoactivation of C1r and C1s serine proteases, forming the active C1 complex and initiating the classical complement cascade.
C1q is a hexamer formed by the association of six C1qA, six C1qB, and six C1qC chains. C1QB contributes to this hexameric structure, which is essential for the recognition of immune complexes.
Mutations in the C1QB gene can lead to C1q deficiency, which is associated with an increased risk of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Customer Reviews (3)
Write a reviewProduct is worth the price.
Outstanding performance in experiments.
Excellent for biochemical assays.
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