Recombinant Human RAB13 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RAB13-2555H
• Product Overview: RAB13 MS Standard C13 and N15-labeled recombinant protein (NP_002861) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 22.8 kDa
• AA Sequence: MAKAYDHLFKLLLIGDSGVGKTCLI IRFAEDNFNNTYISTIGIDFKIRTV DIEGKKIKLQVWDTAGQERFKTITT AYYRGAMGIILVYDITDEKSFENIQ NWMKSIKENASAGVERLLLGNKCDM EAKRKVQKEQADKLAREHGIRFFET SAKSSMNVDEAFSSLARDILLKSGG RRSGNGNKPPSTDLKTCDKKNTNKC SLGTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RAB13 RAB13, member RAS oncogene family [ Homo sapiens (human) ]
• Official Symbol: RAB13
• Synonyms: RAB13; RAB13, member RAS oncogene family; ras-related protein Rab-13; RAS-associated protein RAB13; growth-inhibiting gene 4 protein; cell growth-inhibiting gene 4 protein; GIG4
• Gene ID: 5872
• mRNA Refseq: NM_002870
• Protein Refseq: NP_002861
• MIM: 602672
• UniProt ID: P51153

Reviews

08/24/2022

It is very suitable for testing the rate of enzymatic reactions, and it performs very well.

12/23/2021

RAB13 has a good labeling effect and can be used for fluorescent labeling, etc.

11/25/2020

The clearance rate is high and the harm to the human body is small.

Q&As

What are the mutation types of RAB13?

The mutation types of RAB13 include point mutations, insertions, and deletions. Some of these mutations may cause dysfunction of RAB13, while others may affect its interaction with other proteins.

Who is at high risk of RAB13 mutations?

For people at high risk of RAB13 mutations, including those with cancer or other RAB13-related diseases, genetic testing can help doctors diagnose the condition more accurately and develop a corresponding treatment plan.

Can RAB13 mutations assess the impact of RAB13 mutations on disease progression?

The impact of RAB13 mutations on disease progression can be assessed through in-depth analysis of the patient's genomic data. This can help doctors better understand the patient's condition and develop more effective treatment plans.

How can bioinformatics methods analyze the impact of RAB13 mutations on disease?

Its effect on disease can be predicted by comparing the structure and sequence of mutant and wild-type proteins. This can help doctors better understand the patient's condition and develop more effective treatment plans.

How should treatment strategies for patients with RAB13 mutations be considered in clinical practice?

In clinical practice, treatment strategies for patients with RAB13 mutations need to consider the patient's specific condition, genotype, and treatment goals. Doctors can develop a personalized treatment plan based on the patient's actual situation to improve the treatment effect and maximize the patient's quality of life.

How can I detect the expression level of RAB13?

The expression level of RAB13 can be detected by immunohistochemistry, western blotting, real-time PCR, etc. These methods can detect protein or mRNA levels of RAB13 in tissues or cells to assess changes in its expression in disease.