Recombinant Human RXRG Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RXRG-3882H
• Product Overview: RXRG MS Standard C13 and N15-labeled recombinant protein (NP_008848) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 50.9 kDa
• AA Sequence: MYGNYSHFMKFPAGYGGSPGHTGST SMSPSAALSTGKPMDSHPSYTDTPV SAPRTLSAVGTPLNALGSPYRVITS AMGPPSGALAAPPGINLVAPPSSQL NVVNSVSSSEDIKPLPGLPGIGNMN YPSTSPGSLVKHICAICGDRSSGKH YGVYSCEGCKGFFKRTIRKDLIYTC RDNKDCLIDKRQRNRCQYCRYQKCL VMGMKREAVQEERQRSRERAESEAE CATSGHEDMPVERILEAELAVEPKT ESYGDMNMENSTNDPVTNICHAADK QLFTLVEWAKRIPHFSDLTLEDQVI LLRAGWNELLIASFSHRSVSVQDGI LLATGLHVHRSSAHSAGVGSIFDRV LTELVSKMKDMQMDKSELGCLRAIV LFNPDAKGLSNPSEVETLREKVYAT LEAYTKQKYPEQPGRFAKLLLRLPA LRSIGLKCLEHLFFFKLIGDTPIDT FLMEMLETPLQITTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RXRG retinoid X receptor gamma [ Homo sapiens (human) ]
• Official Symbol: RXRG
• Synonyms: RXRG; retinoid X receptor, gamma; retinoic acid receptor RXR-gamma; NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC
• Gene ID: 6258
• mRNA Refseq: NM_006917
• Protein Refseq: NP_008848
• MIM: 180247
• UniProt ID: P48443

Reviews

05/07/2018

Aids in groundbreaking discoveries, highly recommended.

12/29/2017

Outstanding protein analysis, a research asset.

08/01/2017

Enables data-driven decisions in our research.

Q&As

How do variations in the RXRG gene affect its function and contribute to disease?

Genetic mutations in RXRG can disrupt its regulatory roles, leading to various developmental and metabolic disorders.

What is the significance of RXRG in the regulation of metabolic pathways and homeostasis?

RXRG is key in regulating lipid and glucose metabolism, playing a role in metabolic homeostasis.

What role does RXRG play in developmental processes and organogenesis?

RXRG is essential in embryonic development and organ formation, guiding cell fate decisions.

What is the primary function of RXRG in cellular signaling and gene regulation?

RXRG functions as a nuclear receptor, regulating gene expression in response to ligand binding.

What potential does RXRG have as a therapeutic target in metabolic and degenerative diseases?

Targeting RXRG in therapy offers potential in treating metabolic syndromes and degenerative diseases.

How does RXRG interact with retinoids and what is its role in vitamin A metabolism?

It interacts with retinoids to modulate vitamin A metabolism, influencing cellular differentiation and proliferation.

How does RXRG contribute to the immune system's function and response?

It influences immune function by affecting the development and differentiation of immune cells.