Recombinant Human SYT3, His-tagged

• Cat.No.: SYT3-144H
• Product Overview: SYT3, 76-590aa, Human, His tag, E.coli

Specification

• Description: SYT3, also known as synaptotagmin-3, belongs to the synaptotagmin family. It may be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Recombinant human SYT3 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
• Molecular Mass: 57.7 kDa (540aa)
• Protein length: 76-590aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSEFWKLCW VPWRDKGGSA VGGGPLRKDL GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SYT3 synaptotagmin III [ Homo sapiens ]
• Official Symbol: SYT3
• Synonyms: SytIII
• Gene ID: 84258
• mRNA Refseq: NM_032298.2
• Protein Refseq: NP_115674.1
• MIM: 600327
• UniProt ID: Q9BQG1
• Chromosome Location: 19q13.33
• Function: metal ion binding;transporter activity

Reviews

07/18/2021

Its purity and consistency enable accurate and precise data analysis, ensuring the integrity of my research outcomes.

02/09/2017

the SYT3 protein's exceptional quality, reliability, and the manufacturer's unparalleled technical support make it a prime choice for researchers seeking to delve into the intricacies of angiogenesis, vascular development, and related fields.

07/10/2016

As a researcher utilizing the SYT3 protein in my trials, I have been highly impressed with its numerous advantages that significantly contribute to the success of my experimental endeavors.

Q&As

How does SYT3 contribute to the regulation of calcium signaling in neurons?

SYT3's calcium-binding properties are essential for its role in synaptic vesicle fusion, contributing to the finely tuned calcium signaling necessary for proper neuronal function.

How can SYT3 protein be utilized in diagnostics?

SYT3 levels or mutations might serve as biomarkers for neurological disorders, aiding in the development of diagnostic tools to identify and understand these conditions.

Are there any genetic mutations associated with SYT3 and neurological disorders?

Research suggests that genetic variations in SYT3 may be linked to certain neurological conditions, providing insights into potential genetic markers for susceptibility.

Can SYT3 be a target for drug development?

Explore the potential of SYT3 as a target for drug development, considering its role in neurotransmitter release and synaptic function.

Are there any ongoing clinical trials targeting SYT3 for therapeutic interventions?

Investigate current research and clinical trials focused on modulating SYT3 function as a potential therapeutic strategy for neurological disorders.