Recombinant Human TCF7L2 Protein (1-456 aa), His-tagged

• Cat.No.: TCF7L2-2068H
• Product Overview: Recombinant Human TCF7L2 Protein (1-456 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Partial.

Specification

• Description: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 54.9 kDa
• Protein length: 1-456 aa
• AA Sequence: MPQLNGGGGDDLGANDELISFKDEG EQEEKSSENSSAERDLADVKSSLVN ESETNQNSSSDSEAERRPPPRSESF RDKSRESLEEAAKRQDGGLFKGPPY PGYPFIMIPDLTSPYLPNGSLSPTA RTLHFQSGSTHYSAYKTIEHQIAVQ YLQMKWPLLDVQAGSLQSRQALKDA RSPSPAHIVSNKVPVVQHPHHVHPL TPLITYSNEHFTPGNPPPHLPADVD PKTGIPRPPHPPDISPYYPLSPGTV GQIPHPLGWLVPQQGQPVYPITTGG FRHPYPTALTVNASMSRFPPHMVPP HHTLHTTGIPHPAIVTPTVKQESSQ SDVGSLHSSKHQDSKKEEEKKKPHI KKPLNAFMLYMKEMRAKVVAECTLK ESAAINQILGRRWHALSREEQAKYY ELARKERQLHMQLYPGWSARDNYGK KKKRKRDKQPGETNEHSECFLNPCL SLPPIT
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) [ Homo sapiens ]
• Official Symbol: TCF7L2
• Synonyms: TCF7L2; TCF4; TCF 4; hTCF-4; T-cell factor 4; TCF-4
• Gene ID: 6934
• mRNA Refseq: NM_001146274
• Protein Refseq: NP_001139746
• MIM: 602228
• UniProt ID: Q9NQB0

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02/28/2021

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10/27/2018

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Q&As

How does TCF7L2 interact with other transcription factors and signaling molecules?

TCF7L2 works in concert with other transcription factors and signaling molecules to regulate gene expression.

How do genetic variations in the TCF7L2 gene affect its function and contribute to disease susceptibility?

Genetic variations in TCF7L2 can significantly impact its function, increasing susceptibility to diabetes and other conditions.

What are the implications of altered TCF7L2 activity in cancer biology?

Altered TCF7L2 activity is associated with various cancers, affecting tumor growth and metastasis.

What is TCF7L2's function in Wnt signaling pathway and its impact on cell proliferation and differentiation?

In the Wnt signaling pathway, TCF7L2 regulates genes involved in cell growth, proliferation, and differentiation.

What potential therapeutic strategies could target TCF7L2 in various diseases, including diabetes and cancer?

Targeting TCF7L2 in therapies could offer new approaches in managing diabetes and certain cancers.

What is the primary role of TCF7L2 in gene regulation and cellular signaling?

TCF7L2 is a transcription factor that regulates gene expression, playing a crucial role in various cellular processes.

How does TCF7L2 influence the development and progression of diabetes, particularly type 2 diabetes?

It is strongly linked to type 2 diabetes risk, influencing insulin secretion and glucose metabolism.