Recombinant Human TCF7L2 protein, His-tagged

• Cat.No.: TCF7L2-3308H
• Product Overview: Recombinant Human TCF7L2 protein(1-355 aa), fused to His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein length: 1-355 aa
• AA Sequence: MPQLNGGGGDDLGANDELISFKDEG EQEEKSSENSSAERDLADVKSSLVN ESETNQNSSSDSEAERRPPPRSESF RDKSRESLEEAAKRQDGGLFKGPPY PGYPFIMIPDLTSPYLPNGSLSPTA RTYLQMKWPLLDVQAGSLQSRQALK DARSPSPAHIVSNKVPVVQHPHHVH PLTPLITYSNEHFTPGNPPPHLPAD VDPKTGIPRPPHPPDISPYYPLSPG TVGQIPHPLGWQGQPVYPITTGGFR HPYPTALTVNASMSRFPPHMVPPHH TLHTTGIPHPAIVTPTVKQESSQSD VGSLHSSKHQDSKKEEEKKKPHIKK PLNAFMLYMKEMRAKVVAECTLKES AAINQ
• Purity: 95%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) [ Homo sapiens ]
• Official Symbol: TCF7L2
• Synonyms: TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box); TCF4; transcription factor 7-like 2; TCF 4; hTCF-4; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; HMG box transcription factor 4; T-cell-specific transcription factor 4; TCF-4
• Gene ID: 6934
• mRNA Refseq: NM_001146274
• Protein Refseq: NP_001139746
• MIM: 602228
• UniProt ID: Q9NQB0

Reviews

02/28/2021

Exceptional expertise, elevates our research outcomes.

10/27/2018

Exemplary service, vital for our studies.

07/17/2017

Timely and accurate results, invaluable for research.

Q&As

How does TCF7L2 interact with other transcription factors and signaling molecules?

TCF7L2 works in concert with other transcription factors and signaling molecules to regulate gene expression.

How do genetic variations in the TCF7L2 gene affect its function and contribute to disease susceptibility?

Genetic variations in TCF7L2 can significantly impact its function, increasing susceptibility to diabetes and other conditions.

What are the implications of altered TCF7L2 activity in cancer biology?

Altered TCF7L2 activity is associated with various cancers, affecting tumor growth and metastasis.

What is TCF7L2's function in Wnt signaling pathway and its impact on cell proliferation and differentiation?

In the Wnt signaling pathway, TCF7L2 regulates genes involved in cell growth, proliferation, and differentiation.

What potential therapeutic strategies could target TCF7L2 in various diseases, including diabetes and cancer?

Targeting TCF7L2 in therapies could offer new approaches in managing diabetes and certain cancers.

What is the primary role of TCF7L2 in gene regulation and cellular signaling?

TCF7L2 is a transcription factor that regulates gene expression, playing a crucial role in various cellular processes.

How does TCF7L2 influence the development and progression of diabetes, particularly type 2 diabetes?

It is strongly linked to type 2 diabetes risk, influencing insulin secretion and glucose metabolism.