Recombinant Human TDP1 Protein, His-Tagged

• Cat.No.: TDP1-01H
• Product Overview: Recombinant human TDP1 protein, His-tagged was expressed in Baculovirus

Specification

• Description: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
• Source: Baculovirus
• Species: Human
• Tag: His
• Applications: SDS-PAGE
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Purity: > 90% by SDS-PAGE
• Storage Buffer: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
• Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by absorbance at 280nm)
• Molecular Mass: 69.5 kDa (617aa)
• Protein length: 1-608aa

Gene Information

• Gene Name: TDP1 tyrosyl-DNA phosphodiesterase 1 [ Homo sapiens (human) ]
• Official Symbol: TDP1
• Synonyms: tyrosyl-DNA phosphodiesterase 1 isoform a, TDP1, Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1
• Gene ID: 55775
• mRNA Refseq: NM_001008744.2
• Protein Refseq: NP_060789.2
• UniProt ID: Q9NUW8
• MIM: 607198

Reviews

07/14/2022

Very professional customer service, fully understanding the needs of the customer and giving professional advice.

06/21/2021

The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.

05/09/2021

Fast and timely shipment helped me to get satisfactory experimental results in short time.

Q&As

What are the effects of inhibiting TDP1 expression?

Inhibition of TDP1 expression induces apoptosis in gastric cancer cells.

What diseases has TDP1 been closely associated with the study of?

TDP1 has been closely associated with the study of diseases such as gastric cancer and lung cancer.

How does the expression level of TDP1 change in lung adenocarcinoma tissues?

Lung adenocarcinoma tissues expressed higher levels of TDP1 compared to paraneoplastic and normal tissues.

What is the biological function of TDP1?

TDP1 is involved in DNA damage repair and plays a driving role in tumorigenesis and development.