Recombinant Mouse Tdp1 Protein, MYC/DDK-tagged

• Cat.No.: Tdp1-270M
• Product Overview: Purified recombinant protein of full-length mouse tyrosyl-DNA phosphodiesterase 1 (cDNA clone MGC:30935 IMAGE:4018534), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Broad expression in testis adult (RPKM 14.7), CNS E14 (RPKM 6.9) and 22 other tissues.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 38.9 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tdp1 tyrosyl-DNA phosphodiesterase 1 [ Mus musculus (house mouse) ]
• Official Symbol: Tdp1
• Synonyms: Tdp1; tyrosyl-DNA phosphodiesterase 1; SCAN1; Gm40556; MLZ-501; AI838772; AW493413; 2810481F14Rik; 4921509N21Rik; E430034L06Rik; tyrosyl-DNA phosphodiesterase 1; protein expressed in male leptotene and zygotene spermatocytes 501; tyr-DNA phosphodiesterase 1; tyrosyl-DNA phodphodiesterase 1; EC 3.1.4.-
• Gene ID: 104884
• mRNA Refseq: NM_028354
• Protein Refseq: NP_082630
• UniProt ID: B8JJC1

Reviews

07/14/2022

Very professional customer service, fully understanding the needs of the customer and giving professional advice.

06/21/2021

The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.

05/09/2021

Fast and timely shipment helped me to get satisfactory experimental results in short time.

Q&As

What are the effects of inhibiting TDP1 expression?

Inhibition of TDP1 expression induces apoptosis in gastric cancer cells.

What diseases has TDP1 been closely associated with the study of?

TDP1 has been closely associated with the study of diseases such as gastric cancer and lung cancer.

How does the expression level of TDP1 change in lung adenocarcinoma tissues?

Lung adenocarcinoma tissues expressed higher levels of TDP1 compared to paraneoplastic and normal tissues.

What is the biological function of TDP1?

TDP1 is involved in DNA damage repair and plays a driving role in tumorigenesis and development.