Recombinant Mouse ALG2 Protein
Cat.No. : | ALG2-1546M |
Product Overview : | Recombinant Mouse ALG2 full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Mouse |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Alg2 asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase) [ Mus musculus ] |
Official Symbol : | ALG2 |
Gene ID : | 56737 |
mRNA Refseq : | NM_019998.3 |
Protein Refseq : | NP_064382.3 |
MIM : | |
UniProt ID : | Q9DBE8 |
Products Types
◆ Recombinant Protein | ||
ALG2-466M | Recombinant Mouse ALG2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALG2-131R | Recombinant Rhesus Macaque ALG2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Alg2-1598M | Recombinant Mouse Alg2 Protein, Myc/DDK-tagged | +Inquiry |
ALG2-01H | Recombinant Human ALG2 Protein, Myc/DDK-tagged | +Inquiry |
ALG2-463H | Recombinant Human ALG2 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ALG2-8906HCL | Recombinant Human ALG2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (18)
Ask a questionThis mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.
ALG2 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.
ALG2 regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG3 and ALG1.
A number of inhibitors have been developed that target ALG2 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.
The catalyzes the sugar chain transfer reaction between UDP-glucose and substrate proteins, synthesizing sugar chains onto proteins.
No studies have confirmed whether ALG2 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.
Although there are currently no studies demonstrating the function of ALG2 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.
ALG2 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.
Overexpression or knockout of ALG2 can negatively affect cellular glycosylation and the stability of ER and Golgi bodies, but the specific effects need to be further explored.
This protein selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.
ALG2 is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.
At present, there is no direct evidence that ALG2 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.
There is currently no direct evidence that ALG2 is associated with neurological diseases, but glycosylation plays a key role in nervous system development and function, so there may be a correlation with neurological diseases.
This gene contains 10 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.
ALG2 is mainly distributed in the endoplasmic reticulum (ER) and the Golgi apparatus.
At present, there is no direct evidence that ALG2 mutations are directly related to some diseases, but glycosylation plays an important role in metabolism and disease development, so it may be related to related diseases.
The protein interacts with members of the glycosylase family such as ALG3, ALG1 and other related proteins to jointly regulate the glycosylation process of proteins.
There is no direct evidence that ALG2 is involved in the occurrence and development of metabolic diseases, but it may be associated with related metabolic diseases.
Customer Reviews (4)
Write a reviewIn immunological experiments, ALG2 was found to have good antigenicity and could induce target immune responses.
The high solubility of ALG2 makes it easy to prepare the desired concentration.
The high catalytic efficiency of ALG2 was found in enzymatic experiments.
It was observed that ALG2 had better crystallinity, which was beneficial for crystallographic studies.
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