Recombinant Mouse ANO5 Protein Pre-coupled Magnetic Beads
Cat.No. : | ANO5-570M-B |
Product Overview : | The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations. |
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Source : | HEK293 |
Species : | Mouse |
Form : | Solution |
Particle size : | ~2 μm |
Beads Surface : | Hydrophilic |
Capacity : | > 200 pmol rabbit IgG/ mg beads |
Applications : | Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification. |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. |
Storage : | 2-8℃. Do not to freeze thaw the Beads |
Concentration : | 10mg beads/mL |
Storage Buffer : | PBS buffer |
Gene Name : | Ano5 anoctamin 5 [ Mus musculus ] |
Official Symbol : | ANO5 |
Gene ID : | 233246 |
mRNA Refseq : | NM_177694.5 |
Protein Refseq : | NP_808362.2 |
UniProt ID : | Q75UR0 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (22)
Ask a questionCurrently, there is limited information on the involvement of ANO5 protein in cancer. Some studies have suggested a potential association between ANO5 expression and certain cancer types. However, more research is needed to determine the exact role, if any, of ANO5 in cancer development or progression.
Yes, ANO5 mutations have been associated with gnathodiaphyseal dysplasia, a rare bone disorder characterized by increased bone density, tooth abnormalities, and fractures. The exact mechanisms by which ANO5 mutations lead to bone abnormalities are not fully understood.
While ANO5 mutations are primarily associated with Miyoshi muscular dystrophy type 3, they have also been identified in some cases of limb-girdle muscular dystrophy and distal myopathy. These findings suggest a broader role for ANO5 in muscle-related conditions.
Yes, ANO5 protein has been suggested to be involved in membrane trafficking processes. It interacts with proteins involved in vesicle fusion and intracellular transport, indicating its potential role in regulating membrane dynamics.
ANO5-related muscle disorders include Miyoshi muscular dystrophy type 3 (MMD3), limb-girdle muscular dystrophy type 2L (LGMD2L), and distal myopathy (DM). These disorders are characterized by progressive muscle weakness and atrophy, typically affecting the lower limbs first.
The understanding of ANO5-related disorders is still evolving, and the identification of specific therapeutic targets is an ongoing area of research. However, strategies such as gene therapy, muscle-specific gene delivery, and modulation of calcium-activated chloride channels hold promise as potential therapeutic avenues.
Mutations in the ANO5 gene can lead to abnormal protein function or reduced protein levels, which disrupts normal muscle membrane repair mechanisms. This disruption compromises muscle health and can contribute to the development of muscular dystrophies.
ANO5 protein has been implicated in the repair of damaged muscle cell membranes. It is thought to participate in the resealing of membrane disruptions by facilitating the fusion of intracellular vesicles with the damaged membrane, thus preventing the loss of cellular contents and maintaining membrane integrity.
Yes, ANO5 mutations have been associated with muscle inflammation. In some cases, individuals with ANO5-related muscle disorders may experience ongoing muscle inflammation, which can contribute to muscle weakness and damage.
Yes, ANO5 mutations have been associated with cardiomyopathy, particularly dilated cardiomyopathy, which is a condition characterized by the enlargement of the heart chambers and reduced cardiac function.
ANO5 protein shares structural similarities with other members of the Anoctamin family, including conserved transmembrane domains and intracellular loops. These proteins have similar overall architectures.
While ANO5's functions in non-muscle tissues are not fully understood, studies have suggested its involvement in processes such as cell migration, calcium signaling, and lipid metabolism. However, further research is needed to elucidate its specific roles in these contexts.
Currently, there are no specific therapies or treatments available for ANO5-related disorders. Management of these conditions typically involves symptomatic and supportive care, such as physical therapy and orthopedic interventions, to address muscle weakness and associated complications.
ANO5 protein has been implicated in calcium-dependent signaling, although the exact mechanisms are not fully understood. It may participate in calcium homeostasis and intracellular calcium signaling pathways.
ANO5 protein is known to function as a calcium-activated chloride channel. It can mediate calcium-dependent chloride currents, which are involved in various physiological processes, including cell volume regulation and secretion.
Yes, ANO5 protein has been shown to interact with and regulate certain ion channels, such as the calcium-activated chloride channels (CaCCs). It can modulate their activity and calcium-dependent signaling pathways.
ANO5 protein plays a role in muscle regeneration by participating in the repair process of injured muscle fibers. It aids in the incorporation of new membrane material to the damaged areas, facilitating the restoration of functional muscles.
Yes, various animal models, including mouse and zebrafish models, have been generated to study ANO5-related diseases. These models help researchers understand the molecular mechanisms underlying these disorders and explore potential therapeutic approaches.
Currently, there are no specific inhibitors or activators of ANO5 protein that have been widely characterized. Further research is needed to identify such molecules.
Yes, mutations in the ANO5 gene have been linked to several genetic disorders, including Miyoshi muscular dystrophy 3 (MMD3) and gnathodiaphyseal dysplasia. These disorders affect muscle and bone development.
Yes, ANO5 protein has been shown to interact with several other proteins. For example, it interacts with dysferlin, a protein involved in muscular dystrophy, and myomatrin, another member of the Anoctamin family. These interactions may be important for ANO5's normal function and regulation.
The potential use of ANO5 protein as a biomarker for specific diseases is still being investigated. However, some studies have suggested its potential as a biomarker for certain types of muscular dystrophies. Further research is needed in this area.
Customer Reviews (4)
Write a reviewthe high-quality ANO5 protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.
The knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.
This enables researchers to confidently incorporate ANO5 into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.
the ANO5 protein is carefully characterized, and its functional properties are well-documented.
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