ROCK1
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Official Full Name
Rho-associated, coiled-coil containing protein kinase 1
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Overview
ROCK-1, a 160 kDa small-GTP-effector protein, is a serine/threonine kinase involved in the induction of focal adhesions and stress fibers, and can play a major role in vascular smooth muscle contraction, malignant cell transformation, tumor invasion and m -
Synonyms
ROCK1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated protein kinase 1; p160ROCK; p160-ROCK; Rho kinase; p160 ROCK-1; renal carcinoma antigen NY-REN-35; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coil;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His,HA
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- ROCK1 Related Signal Pathway
ROCK1 involved in several pathways and played different roles in them. We selected most pathways ROCK1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | ATP1B3;VASP;PPP1R12A;PPIF;CALM3;AKT1;INS1;ATP2B1;ATP1A2 |
| cAMP signaling pathway | FXYD2;GRIN2A;GNAS;CREB5;CALML3;PRKACG;HHIP;HTR1E;PIK3R5 |
| Chemokine signaling pathway | PRKCB;CCL20;GNG7;GNGT2;GRK6;CCL5;KRAS;HCK;PIK3CG |
| Sphingolipid signaling pathway | PPP2R5C;BDKRB2;PRKCA;SPTLC1;MAPK3;SGPL1;S1PR4;CERS4;KRAS |
| Vascular smooth muscle contraction | PRKACAA;CALM2A;AGTR1B;CYP4A10;PRKCA;GNA11A;PLA2G4AA;PLA2G4F;PLA2G6 |
| TGF-beta signaling pathway | TFDP1A;GDF5;PPP2CA;NOG3;RHOAC;ACVR2AA;RHOAB;CUL1A;SMURF1 |
| Axon guidance | UNC5D;RNF8;ACTR3;WDR83;CRMP1;RAC3;PTPRA;EFNB1;TRPC5 |
| Focal adhesion | THBS3;SRC;RAP1AA;LAMA2;VEGFB;PARVA;XIAP;MYLPFB;ITGA8 |
| Platelet activation | PIK3R2;PPP1CC;PRKACG;NOS3;MYL12A;ITPR3;SNAP23;P2RY12;FGB |
| Leukocyte transendothelial migration | GNAI3;RHOH;RHOA;RAP1B;PLCG2;PIK3CA;PIK3CD;CLDN8;CXCR4 |
| Regulation of actin cytoskeleton | FGF4;GNG12;VAV2;FGF22;PIK3CD;ITGA7;PIK3R3;PFN2L;ITGA4 |
| Oxytocin signaling pathway | PIK3CD;PRKAG1;ACTB;MYL6B;PPP3R1;GUCY1A3;CACNG8;PPP1CB;ITPR1 |
| Pathogenic Escherichia coli infection | TUBA1B;EZR;TUBA4A;LY96;TLR4;TUBA1C;TUBA3D;TUBA3C;CDC42 |
| Shigellosis | RAC1;RELA;CTTN;UBE2D2;WASL;RHOG;MAPK13;PFN2;FBXW11 |
| Salmonella infection | ARPC5L;MAPK12B;NOS2;KLC1A;NFKB1;WASL;RHOGB;IL-8;MAPK12 |
| Pathways in cancer | PPARD;FGF22;PIK3CA;BRCA2;MSH3;BIRC8;NFKB2;NTRK1;SMAD4 |
| Proteoglycans in cancer | ACTB;PIK3CB;FLNA;RHOA;CCND1;CAMK2G;FGFR1;PRKACA;PIK3R3 |
| MicroRNAs in cancer | PDGFRB;GLS;TRP63;RAF1;BMF;WNT3A;BAK1;PTGS2;SOS1 |
ROCK1 has several biochemical functions, for example, ATP binding, GTP-Rho binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK1 itself. We selected most functions ROCK1 had, and list some proteins which have the same functions with ROCK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PIK3C2G;NEK9;UBE2B;PRKX;NRK;DGKE;MAST2;ACTR1B;GC2 |
| GTP-Rho binding | TNFAIP1;CDC42EP3;ROCK1;CDC42EP2;WHAMM;KCTD13;ROCK2B;CDC42EP1B;CDC42EP4A |
| metal ion binding | ZFP704;ZFP629;POLB;ZMYM2;CNOT4B;GPHN;ASXL1;MICALL2;MGRN1A |
| protein binding | RQCD1;IL6ST;COG4;CCNK;ZBTB22;MDH1;PSG5;PTCRA;G3BP2 |
| protein kinase activity | PRKCA;TRIM28;PDK3;PAK1;PKN2;ABL1;PTK2BB;POMK;NPRL2 |
| protein serine/threonine kinase activity | ULK3;IKBKB;AURKB;SRPK3;KSR2;PIM3;PRKCB;AKT2;PRKACAA |
ROCK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK1.
RHOA; MAGEB4; LMO2; FAM124A; C6orf165; POLR3C; MYBPH
Research Area
Related articles
- Q&As
- Reviews
Q&As (7)
Ask a questionROCK1 plays a significant role in vascular tone regulation, impacting blood pressure and cardiovascular function.
ROCK1 regulates inflammatory processes, influencing immune cell activity and inflammation.
ROCK1 influences cancer progression, particularly in aspects of cell invasion, metastasis, and tumor growth.
ROCK1 controls cytoskeletal rearrangements, crucial for cell shape, movement, and division.
ROCK1 is involved in neurological disorders by affecting neuronal cytoskeletal dynamics and synaptic function.
ROCK1 modulates apoptosis, playing a role in determining cell survival or programmed cell death.
Changes in ROCK1 activity impact tissue remodeling and fibrosis, affecting wound healing and disease progression.
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