ALKBH1
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Official Full Name
alkB, alkylation repair homolog 1
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Overview
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. -
Synonyms
ALKBH1; alkB, alkylation repair homolog 1 (E. coli); alkB, alkylation repair homolog (E. coli) , ALKBH; alkylated DNA repair protein alkB homolog 1; ABH; alkB; hABH; DNA lyase ABH1; alkylation repair, alkB homolog; alpha-ketoglutarate-dependent dioxygenas;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ALKBH1 involved in several pathways and played different roles in them. We selected most pathways ALKBH1 participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Integrated Breast Cancer Pathway | RPP38;BACH1;EDAR;JAKMIP1;UBE2F;GDI1;APOBEC3G;NAB1;CCNB1IP1 |
ALKBH1 has several biochemical functions, for example, DNA-(apurinic or apyrimidinic site) lyase activity, ferrous iron binding, methylcytosine dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH1 itself. We selected most functions ALKBH1 had, and list some proteins which have the same functions with ALKBH1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA-(apurinic or apyrimidinic site) lyase activity | RPS3;NEIL2;NTHL1;HMGA1-RS1;HMGA1A;HMGA1B;APEX1;ALKBH1;NEIL1 |
ferrous iron binding | TET2;ISCUB;CDO1;ALKBH2;TH;FECH;SNCA;SERPINB1A;ALKBH1 |
methylcytosine dioxygenase activity | TET1;TET2;ALKBH1;TET3 |
ALKBH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH1.
- Q&As
- Reviews
Q&As (17)
Ask a questionALKBH1 can remove oxidative components and methylation markers from DNA, and is involved in DNA base repair and oxidative stress.
By studying the expression and function of ALKBH1 in liver cancer tissue, we can understand its role in the treatment of liver cancer.
ALKBH1 is mainly expressed in liver, spleen, myocardium and other tissues.
ALKBH1 plays a key role in the development and progression of gastric cancer, which may be related to the regulation of DNA repair and apoptosis.
The study on the expression level of ALKBH1 in metabolic diseases can provide new ideas for the prediction and treatment of metabolic diseases.
It can influence the function of the immune system and the occurrence of inflammatory responses, regulating cell state by removing oxidative components and methylation markers.
It has been shown to play an important role in neurological and related disorders, including mild cognitive impairment.
The expression may be regulated by various environmental factors and endogenous signals, including chemical stimulation and oxidative stress.
ALKBH1 plays a key role in DNA damage and repair, repairing 1- or 3-methyladenine in DNA.
This protein plays an important role in the occurrence and development of cardiovascular diseases, which may be related to lipid metabolism and pathway regulation.
ALKBH1 plays an important role in mammalian stem cell reprogramming, promoting stem cell proliferation and differentiation.
The mutation may affect metabolic capacity and cause liver disease, diabetes, obesity and other related diseases.
It can remove 1- or 3-methyladenine from DNA and is involved in DNA methylation repair and DNA repair processes.
The mutation may be associated with cancer, cardiovascular disease, liver disease, etc.
ALKBH1 repairs DNA damage by removing 1- or 3-methyladenine from DNA double-stranded DNA in an oxygen-dependent manner.
The expression and role of ALKBH1 in certain diseases can be comprehensively evaluated through comparative omics, immunopathology, molecular biology and other research methods, so as to provide references for disease prediction and treatment.
ALKBH1 is involved in a variety of cell signaling pathways, including NF-κB.
Customer Reviews (4)
Write a reviewCan meet the specific experimental requirements and research purposes when used in experiments.
The products are available in a wide range of specifications for different sizes and experimental designs.
When ALKBH1 was used in the experiment, clear and consistent results could be obtained, which was convenient for data analysis and interpretation.
Long half-life and is able to maintain stability and reliability during the experiment.
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