ALDH1L1
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Official Full Name
aldehyde dehydrogenase 1 family, member L1
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Overview
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning. -
Synonyms
ALDH1L1; aldehyde dehydrogenase 1 family, member L1; formyltetrahydrofolate dehydrogenase , FTHFD; cytosolic 10-formyltetrahydrofolate dehydrogenase; 10 fTHF; cytosolic 10 formyltetrahydrofolate dehydrogenase; 10-FTHFDH; formyltetrahydrofolate dehydrogena;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ALDH1L1 Related Articles
ALDH1L1 involved in several pathways and played different roles in them. We selected most pathways ALDH1L1 participated on our site, such as Folate-Alcohol and Cancer Pathway, One Carbon Metabolism, One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH1L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folate-Alcohol and Cancer Pathway | CYP2E1;ALDH1L1 |
| One Carbon Metabolism | ALDH1L1;MTHFD2;ST20-MTHFS;MTFMT;MTHFS;AHCY;FTCD |
| One carbon pool by folate | MTHFD1B;SHMT2;DHFRL1;MTHFD1;MTHFS;MTFMT;TYMS;MTR;MTHFR |
| folate transformations I | ALDH1L2;ALDH1L1;MTHFSD;MTHFD2 |
ALDH1L1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, catalytic activity, formyltetrahydrofolate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH1L1 itself. We selected most functions ALDH1L1 had, and list some proteins which have the same functions with ALDH1L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde dehydrogenase (NAD) activity | ALDH2;ALDH1B1;ALDH6A1;ALDH3B2;ALDH16A1;ALDH3A2B;ALDH3A2A;ALDH9A1;ALDH7A1 |
| catalytic activity | ACSL1A;BLM;PPM1AB;NRD1B;FH1;DBH;ALDOCB;HSD17B1;PCYT1AB |
| formyltetrahydrofolate dehydrogenase activity | ALDH1L1;ALDH1L2 |
| hydroxymethyl-, formyl- and related transferase activity | ALDH1L2;ALDH1L1 |
| methyltransferase activity | PCMT;PRMT9;EHMT1B;NDUFAF5;C2orf56;SUV39H1B;KIAA1456;ALDH1L1;TYW3 |
ALDH1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH1L1.
SIRT4
- Q&As
- Reviews
Q&As (5)
Ask a questionThe precise role of ALDH1L1 protein in various diseases is still being elucidated, and developing effective therapies targeting this protein presents challenges.
Targeting ALDH1L1 protein may have potential side effects related to its role in folate metabolism and neural stem cell maintenance.
The expression of ALDH1L1 protein can vary significantly across different cancer types, potentially making it a valuable target for personalized therapies.
Research suggests that targeting ALDH1L1 protein could potentially be a strategy for cancer treatment, but further studies are needed to determine its efficacy.
Research suggests that the expression of ALDH1L1 protein may decrease with age, which could have implications for age-related diseases.
Customer Reviews (3)
Write a reviewOne notable advantage of using the ALDH1L1 protein is the outstanding technical support provided by its manufacturer.
The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.
Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.
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