Recombinant Human ALDH1L1 Protein, MYC/DDK-tagged

• Cat.No.: ALDH1L1-474H
• Product Overview: Recombinant Human ALDH1L1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 98.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ALDH1L1 aldehyde dehydrogenase 1 family, member L1 [ Homo sapiens ]
• Official Symbol: ALDH1L1
• Synonyms: ALDH1L1; aldehyde dehydrogenase 1 family, member L1; formyltetrahydrofolate dehydrogenase , FTHFD; cytosolic 10-formyltetrahydrofolate dehydrogenase; 10 fTHF; cytosolic 10 formyltetrahydrofolate dehydrogenase; 10-FTHFDH; formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogenase; aldehyde dehydrogenase family 1 member L1; FDH; FTHFD; 10-fTHF; DKFZp781N0997
• Gene ID: 10840
• mRNA Refseq: NM_012190
• Protein Refseq: NP_036322
• MIM: 600249
• UniProt ID: O75891

Reviews

08/17/2022

One notable advantage of using the ALDH1L1 protein is the outstanding technical support provided by its manufacturer.

04/22/2021

The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.

10/07/2017

Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.

Q&As

What are the current challenges in targeting ALDH1L1 protein for therapeutic purposes?

The precise role of ALDH1L1 protein in various diseases is still being elucidated, and developing effective therapies targeting this protein presents challenges.

What are the potential side effects of targeting ALDH1L1 protein for therapeutic purposes?

Targeting ALDH1L1 protein may have potential side effects related to its role in folate metabolism and neural stem cell maintenance.

How does the expression of ALDH1L1 protein vary in different cancer types?

The expression of ALDH1L1 protein can vary significantly across different cancer types, potentially making it a valuable target for personalized therapies.

Can ALDH1L1 protein be a potential therapeutic target for cancer treatment?

Research suggests that targeting ALDH1L1 protein could potentially be a strategy for cancer treatment, but further studies are needed to determine its efficacy.

How does the expression of ALDH1L1 protein change with age?

Research suggests that the expression of ALDH1L1 protein may decrease with age, which could have implications for age-related diseases.