TF
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Official Full Name
transferrin
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Overview
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] Transferrin is a metal-combining protein that reversibly bound to acid-soluble iron in plasma. It functions to transport iron to the bone marrow and to tissue storage organs such as the liver. Transferrin also participate in the regulation and control of iron absorption and protects against iron intoxication. Like haptoglobin, the carrier of hemoglobin, transferrin is synthesized in the liver, but unlike haptoglobin transferrin is returned to the circulation after unloading its iron in the reticuloendothelial system. This ELISA kit can be used to measure transferrin in serum, tissue extracts and other biological fluids. -
Synonyms
TF; transferrin; TFQTL1; PRO1557; PRO2086; serotransferrin; siderophilin; beta-1 metal-binding globulin; AI266983; Cd176; HP; Tfn; hpx; hypotransferrinemia with hemochromatosis; Apotransferrin; Beta 1 metal binding globulin; DKFZp781D0156; PRO1400; Serotransferrin precursor; Transferin; TRFE_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- GMP Proteins
- Others
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bovine
- Cattle
- Chicken
- Dog
- Gallus gallus (chicken)
- Human
- Monkey
- Mouse
- Pig
- Rabbit
- Rat
- Sheep
- Bovine Serum
- Cattle
- Chicken Egg White
- Chicken Serum
- CHO-K1
- Conalbumin from Chicken egg white
- E.coli
- HEK293
- Human
- Human Cell
- Human plasma
- Human Plasma
- Human Serum
- Mammalian Cell
- Mammalian cells
- Monkey plasma
- Mouse Plasma
- Mouse Serum
- Oryza Sativa
- Pichia pastoris
- Pig
- Rabbit Skeletal Muscle
- Rat
- rat plasma
- Rat Plasma
- Serum
- Sheep Serum
- Yeast
- C
- hFc
- His
- Fc
- Flag
- GST
- His (Fc)
- Avi
- KSI
- mFc
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TF Related Articles
- TF Related Gene Family
- TF Related Research Area
TF involved in several pathways and played different roles in them. We selected most pathways TF participated on our site, such as HIF- signaling pathway, Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with TF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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HIF- signaling pathway | PDHA1;PRKCA;PIK3CA;PFKL;PIK3R3;PLCG1;AKT1;EPO;CAMK2G |
Mineral absorption | Trf;MT1H;ATP1B2;ATP1A4;CYBRD1;MT1B;SLC34A2;SLC26A9;SLC26A3 |
TF has several biochemical functions, for example, ferric iron binding, ferric iron transmembrane transporter activity, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TF itself. We selected most functions TF had, and list some proteins which have the same functions with TF. You can find most of the proteins on our site.
Function | Related Protein |
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ferric iron binding | TH;FTH1A;TF;FTHL17;FXN;Trf;FTMT;FTH1B;ACP5 |
ferric iron transmembrane transporter activity | TF;Trf |
ferrous iron binding | NT5E;ALKBH3;HEPH;ALKBH1;EGLN2;PLOD1;SERPINB1A;DNAJC24;ACP5 |
protein binding | CCBL1;JAK1;TNFAIP3;SVIL;EIF4E2;UBXN1;RBFOX1;DDRGK1;PTPN18 |
transferrin receptor binding | HFE2;Trf;RGMA;SNX2;CD81;SNX1;TF;SNX4;HFE |
TF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TF here. Most of them are supplied by our site. Hope this information will be useful for your research of TF.
GAST; ESR1; TFRC; GTF2F2; MIS12; Akap12; TUBB4A; GRB2; SH3BP2; SMAD3; q99ib8-pro_0000045599; TIMELESS; LAMC3; PTBP3
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, abnormalities in TF proteins can serve as diagnostic markers for certain diseases.
Yes, some drugs target TF proteins, especially in the treatment of cancer.
TF proteins can trigger or suppress immune responses, making them relevant in understanding autoimmune diseases.
TF proteins are vital for understanding disease mechanisms and can be targeted for therapeutic purposes.
Yes, various assays, like ELISA and Western blot, can be used to quantify TF protein levels.
Customer Reviews (3)
Write a reviewTheir team of experts is not only knowledgeable about the TF protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.
This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.
The TF protein is of exceptional quality, making it a perfect fit for my experimental needs.
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