Recombinant Human Aldehyde Dehydrogenase 4 Family, Member A1, GST-tagged

• Cat.No.: ALDH4A1-499H
• Product Overview: RecombinantHuman ALDH4A1 protein was expressed as GST-tagged fusion proteins by E. coli andpurified by GSH-sepharose. The purified ALDH4A1 was resolved in 1M PBS (58mMNa2HPO4, 17mM NaH2PO4, 68mM NaCl,pH8) added with 100mM GSH and 1% Triton X-100, 15% glycerol.

Specification

• Cat. No.: ALDH4A1-499H
• Description: Delta-1-pyrroline-5-carboxylatedehydrogenase, mitochondrial is an enzyme that in humans is encoded by theALDH4A1 gene. This protein belongs to the aldehyde dehydrogenase family ofproteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenasethat catalyzes the second step of the proline degradation pathway, convertingpyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associatedwith type II hyperprolinemia, an autosomal recessive disorder characterizedby accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Twotranscript variants encoding the same protein have been identified for thisgene.
• Host: E. coli.
• Antigen Peptide: C-term-351aa
• Full Length: False
• Buffer: 1MPBS (58mM Na2HPO4, 17mM NaH2PO4,68mM NaCl, pH8) added with 100mM GSH and 1% Triton X-100, 15% glycerol.
• Storage: Theprotein is stored in PBS at -20°C. Repeatedfreeze-thaw cycles should be avoided.

Gene Information

• Gene Name: ALDH4A1 aldehyde dehydrogenase 4family, member A1 [ Homo sapiens ]
• Official Symbol: ALDH4A1
• Synonyms: ALDH4A1; aldehyde dehydrogenase4 family, member A1; P5CD; ALDH4; P5CDh; DKFZp779M035;delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5Cdehydrogenase; OTTHUMP00000002544; OTTHUMP00000002545; OTTHUMP00000002546; aldehydedehydrogenase family 4 member A1; mitochondrial delta-1-pyrroline5-carboxylate dehydrogenase; P5C; P5CDH; EC1.5.1.12
• Gene ID: 8659
• mRNA Refseq: NM_001161504
• Protein Refseq: NP_001154976
• MIM: 606811
• UniProt ID: P30038
• Chromosome Location: 1p36
• Pathway: 4-hydroxyprolinedegradation I; Alanine, aspartate and glutamate metabolism; Alanine andproline metabolism; Metabolic pathways; metabolism;metabolism of amino acids and derivatives; proline catabolism; arginine degradation I (arginase pathway); proline degradation
• Function: 1-pyrroline-5-carboxylate dehydrogenase activity; aldehydedehydrogenase (NAD) activity; electron carrier activity; oxidoreductaseactivity