Recombinant Bovine ASAP1, His-tagged

• Cat.No.: ASAP1-3617B
• Product Overview: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1), partial

Specification

• Source: E. Coli or Yeast
• Species: Bovine
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 1129
• Purity: >90%
• Notes: Small volumes of ASAP1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [ Bos taurus ]
• Official Symbol: ASAP1
• Synonyms: DDEF1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; DEF-1; PIP2-dependent ARF1 GAP; ARF GTPase-activating protein 1; differentiation-enhancing factor 1; development and differentiation enhancing factor 1; development and differentiation-enhancing factor 1
• Gene ID: 327705
• mRNA Refseq: NM_175821
• Protein Refseq: NP_787015
• UniProt ID: O97902
• Chromosome Location: chromosome: 14
• Pathway: EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem
• Function: ARF GTPase activator activity; zinc ion binding

Reviews

12/25/2020

I have found the ASAP1 Protein to be highly stable, enabling long-term experiments without compromising its performance.

05/08/2019

One aspect that sets the ASAP1 Protein apart is the excellent technical support provided by the manufacturer.

01/09/2016

The ASAP1 Protein is an exceptional product that fully meets my experimental needs.

Q&As

How does ASAP1 participate in actin cytoskeleton remodeling?

ASAP1 binds to actin-binding proteins and actin regulatory proteins, enabling it to regulate actin dynamics and cytoskeleton rearrangements in response to cellular signaling.

What cellular processes are regulated by ASAP1's Arf-GAP activity?

ASAP1's Arf-GAP activity influences processes such as endocytosis, exocytosis, membrane recycling, and protein trafficking.

Is ASAP1 expression altered in cancer?

Yes, ASAP1 expression levels can be dysregulated in certain cancer types, leading to increased invasiveness and poor prognosis.

Does ASAP1 play a role in cancer development or progression?

Yes, ASAP1 has been implicated in cancer progression, promoting cell migration, invasion, and metastasis.

Where is ASAP1 primarily localized within cells?

ASAP1 is found predominantly at the plasma membrane, where it participates in various cellular activities.

What other proteins interact with ASAP1?

ASAP1 interacts with various proteins, including members of the Arf family, components of the endocytic machinery, regulators of actin dynamics, and other signal transduction molecules.

Are there any mutations or genetic variations associated with ASAP1?

Mutations or genetic variations in ASAP1 have not been extensively reported, but further research is required to explore their potential associations.