Recombinant Full Length Mouse Uncharacterized Aarf Domain-Containing Protein Kinase 5(Adck5) Protein, His-Tagged
Cat.No. : | RFL10245MF |
Product Overview : | Recombinant Full Length Mouse Uncharacterized aarF domain-containing protein kinase 5(Adck5) Protein (Q80V03) (1-582aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Mus musculus (Mouse) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-582) |
AA Sequence : | MWRPMRLCHFHSTLLQSRQKPWPCP AIFFRRNFKSPPARTSRARLLWRRA LSATVVGTPF LLGAYYFMAEASERRKLRLAVDGIG RFGRSVKIGLFISTDYWWCTNVVLR GVEENSPKYV EIMSACHQRAADALVAGAIRNGGLY VKLGQGLCSFNHLLPTEYIQTLRVL EDKALTRGFR EVDELFLEDFQALPNELFQEFDYEP MAAASLAQVHRAKLHDGTDVAVKVQ YIDLRDRFDG DVQTLELLLRLVELMHPSFGFSWVL QDLKGTLVQELDFENEGRNAERCAQ ELKHFHYVVI PRVHWDRSSKRVLTADFCNGCKVND MEGIKSQGLAVQDVAKKLIQTFAEQ IFHTGFIHSD PHPGNVLVRKGPDGKAELVLLDHGL YQFLDEKDRSSLCQLWRAIILRDNA AMKKHAAALG VQDYMLFSEVLMQRPVRLGQLWGSH LISREEAAYMQDMAREHFDGIMEVL KALPRPMLLV LRNINTVRAINSNLGTPVDRYFLMA KSAVWGWSRLVGAAYQGIYGSSLLR HIKVLWEALK FEMALRLEILAMRLTALMLRVLVRL GFAPKAEAEEVYQYLEM |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | Adck5 |
Synonyms : | Adck5; Uncharacterized aarF domain-containing protein kinase 5 |
UniProt ID : | Q80V03 |
Gene Name : | Adck5 |
Synonyms : | Adck5; Uncharacterized aarF domain-containing protein kinase 5 |
UniProt ID : | Q80V03 |
Products Types
◆ Recombinant Protein | ||
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ADCK5-98H | Recombinant Human ADCK5, GST-tagged | +Inquiry |
ADCK5-9407H | Recombinant Human ADCK5, His-tagged | +Inquiry |
ADCK5-326H | Recombinant Human ADCK5 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ADCK5-11HCL | Recombinant Human ADCK5 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionADCK5 protein may be a target for drug development aimed at improving CoQ10 biosynthesis and mitochondrial function. However, more research is needed to fully understand the role of ADCK5 protein in these processes and to identify potential drug targets.
ADCK5 protein has been shown to play a critical role in CoQ10 biosynthesis, which is important for energy production and mitochondrial function. Therapeutic applications of ADCK5 protein may include the treatment of conditions related to CoQ10 deficiency or mitochondrial dysfunction, such as neurodegenerative diseases, muscle disorders, and heart disease.
There is currently no evidence to suggest that ADCK5 protein supplementation can improve athletic performance. While CoQ10 supplements may be helpful in some cases of mitochondrial dysfunction, their effects on athletic performance have not been well-established.
While ADCK5 protein plays a role in cellular energy production and mitochondrial function, there is no evidence to suggest that ADCK5 protein supplementation can improve cognitive function. However, CoQ10 supplements have been studied for their potential benefits for cognitive function and neurological disorders, and further research is needed to understand the potential role of ADCK5 protein in these conditions.
ADCK5 protein is being studied in various research settings to better understand its role in CoQ10 biosynthesis and mitochondrial function. This includes studies using cell-based models, animal models, and genetic analyses of patients with mitochondrial disorders or CoQ10 deficiency. Researchers are also exploring the potential therapeutic effects of ADCK5 protein and CoQ10 supplementation on various conditions.
While ADCK5 protein is involved in the pathogenesis of PHSP, it is not yet clear whether it can be used as a therapeutic target for the treatment of this condition. However, research is ongoing to explore the potential use of ADCK5 and CoQ10 biosynthesis pathway for the treatment of PHSP.
ADCK5 protein is expressed in many tissues throughout the body, but it is primarily found in tissues with high energy demands, such as the heart, liver, and skeletal muscles. It is also expressed in the brain and nervous system, indicating its potential role in neurological functions.
At present, there is insufficient evidence to support the use of ADCK5 protein as a biomarker for disease diagnosis or prognosis. However, further research may reveal its potential utility as a biomarker for certain conditions, particularly those that involve mitochondrial dysfunction.
Yes, mutations in the ADCK5 gene have been associated with a rare form of progressive hereditary spastic paralysis (PHSP), which is a neurological disorder that affects the spinal cord and causes muscle weakness and stiffness.
Currently, there are no clinical trials for ADCK5 protein therapy, but research is ongoing to explore the potential therapeutic applications of ADCK5 protein or the CoQ10 biosynthesis pathway. It is possible that clinical trials may be developed in the future, particularly for diseases that involve mitochondrial dysfunction.
ADCK5 protein activity is regulated by various factors, including the availability of its substrate (p-aminobenzoate), as well as other enzymes and cofactors involved in the CoQ10 biosynthesis pathway. Additionally, ADCK5 can be phosphorylated, which can affect its enzymatic activity and stability.
Currently, there are no clinical trials specifically focused on ADCK5 protein. However, some clinical trials are investigating the potential therapeutic effects of CoQ10 supplements on various conditions, including Parkinson's disease, heart failure, and muscular dystrophy.
There is currently no evidence to suggest that ADCK5 protein supplementation can improve mitochondrial function. CoQ10 supplements have been studied for their potential benefits for mitochondrial function and energy metabolism, but the effects of ADCK5 protein supplementation are not yet understood.
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