Recombinant Full Length Schizosaccharomyces Pombe Dolichyl-Phosphate Beta-Glucosyltransferase(Alg5) Protein, His-Tagged
Cat.No. : | RFL-31126SF |
Product Overview : | Recombinant Full Length Schizosaccharomyces pombe Dolichyl-phosphate beta-glucosyltransferase(alg5) Protein (O60061) (1-322aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Tag : | His |
Form : | Lyophilized powder |
Protein length : | Full Length (1-322) |
AA Sequence : | MVVYIVLYTCLAGFILLFLVYYYLT HSHCPRKQLEGEETCVFIENGQKKS LTLEKWSTSDNIQITVIVPAYNESK RIGNMLQETVDHLEKYYRSSSSAGQ RRWEILIVDDESKDTTVNAVLEFSN KLDLRDHLRVCSLKRNRGKGGAVTW GMLYARGQYAIFADADGASQFSDLE LLFKNMPPGPRGGVVVGSRAHMVNT AAVVKRSFIRNFLMHCFHKLLQILG IREIGDTQCGFKLFSREAYQSIFPR MHVEGWIFDIEVLTLARFFGLPIIE VPITWHEVGGSKMTLLKDSISMAID LLVIRLNYTFGIWERPSAKRIT |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Applications : | SDS-PAGE |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | alg5 |
Synonyms : | alg5; SPBC56F2.10c; Dolichyl-phosphate beta-glucosyltransferase; DolP-glucosyltransferase; Asparagine-linked glycosylation protein 5 |
UniProt ID : | O60061 |
Gene Name : | alg5 |
Synonyms : | alg5; SPBC56F2.10c; Dolichyl-phosphate beta-glucosyltransferase; DolP-glucosyltransferase; Asparagine-linked glycosylation protein 5 |
UniProt ID : | O60061 |
Products Types
◆ Recombinant Protein | ||
ALG5-468M | Recombinant Mouse ALG5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALG5-132R | Recombinant Rhesus Macaque ALG5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALG5-9577H | Recombinant Human ALG5, His-tagged | +Inquiry |
ALG5-465H | Recombinant Human ALG5 Protein, GST-tagged | +Inquiry |
ALG5-4332Z | Recombinant Zebrafish ALG5 | +Inquiry |
◆ Lysates | ||
ALG5-62HCL | Recombinant Human ALG5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionIt is involved in metabolic pathways such as glycosylation and glucose metabolism.
It is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.
Overexpression or knockout of ALG5 can negatively affect the glycosylation of cells and the stability of ER and Golgi bodies, but the specific effects need to be further explored.
ALG5 plays an important role in protein glycosylation, participating in the synthesis and modification of sugar chains.
ALG5 interacts with members of the glycosylase family such as ALG3, ALG2 and other related proteins to jointly regulate the glycosylation process of proteins.
Although there are currently no studies demonstrating the function of ALG5 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.
ALG5 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.
The ALG5 gene contains 9 exons and its expression is influenced by multiple regulatory elements and signaling pathways.
A number of inhibitors have been developed that target ALG5 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.
ALG5 mutation may lead to the occurrence and development of some metabolic diseases such as CDG, and further investigation is needed to confirm its role in metabolic diseases.
At present, there is no direct evidence that ALG5 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.
No studies have confirmed whether ALG5 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.
The mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.
The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG3 and ALG2.
This protein mutation may be associated with some genetic diseases, such as CDG (Congenital Disorder of Glycosylation).
ALG5 plays an important role in some neurological diseases, such as central nervous system dysplasia, leading to symptoms such as mental retardation.
ALG5 selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.
Customer Reviews (4)
Write a reviewALG5 has been found to induce specific immune responses in immunotherapy, which has potential value for disease treatment.
ALG5 was found to efficiently load and release drugs in drug delivery systems.
In vaccine studies, ALG5 has been found to induce immunoprotective effects and has potential for disease prevention.
In genetic engineering studies, ALG5 has been found to have good application potential in protein engineering and recombinant expression.
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