Recombinant Human ABHD11 Protein, GST-Tagged
Cat.No. : | ABHD11-072H |
Product Overview : | Human ABHD11 full-length ORF ( NP_683710.1, 1 a.a. - 315 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a protein containing an alpha/beta hydrolase fold domain. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. [provided by RefSeq, Mar 2016] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 61.1 kDa |
AA Sequence : | MRAGQQLASMLRWTRAWRLPREGLG PHGPSFARVPVAPSSSSGGRGGAEP RPLPLSYRLLDGEAALPAVVFLHGL FGSKTNFNSIAKILAQQTGRRVLTV DARNHGDSPHSPDMSYEIMSQDLQD LLPQLGLVPCVVVGHSMGGKTAMLL ALQRPELVERLIAVDISPVESTGVS HFATYVAAMRAINIADELPRSRARK LADEQLSSVIQDMAVRQHLLTNLVE VDGRFVWRVNLDALTQHLDKILAFP QRQESYLGPTLFLLGGNSQFVHPSH HPEIMRLFPRAQMQTVPNAGHWIHA DRPQDFIAAIRGFLV |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ABHD11 abhydrolase domain containing 11 [ Homo sapiens ] |
Official Symbol : | ABHD11 |
Synonyms : | ABHD11; abhydrolase domain containing 11; WBSCR21, Williams Beuren syndrome chromosome region 21; abhydrolase domain-containing protein 11; PP1226; Williams Beuren syndrome chromosome region 21; williams-Beuren syndrome chromosomal region 21 protein; WBSCR21; |
Gene ID : | 83451 |
mRNA Refseq : | NM_001145364 |
Protein Refseq : | NP_001138836 |
UniProt ID : | Q8NFV4 |
Products Types
◆ Recombinant Protein | ||
ABHD11-1062M | Recombinant Mouse ABHD11 Protein (1-307 aa), His-SUMO-tagged | +Inquiry |
ABHD11-1747M | Recombinant Mouse ABHD11 Protein (1-307 aa), His-tagged | +Inquiry |
Abhd11-1466M | Recombinant Mouse Abhd11 Protein, Myc/DDK-tagged | +Inquiry |
ABHD11-1236Z | Recombinant Zebrafish ABHD11 | +Inquiry |
◆ Lysates | ||
ABHD11-9140HCL | Recombinant Human ABHD11 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionABHD11 is a potential biomarker of lung adenocarcinoma, and is linked to breast cancer malignancy.
ABHD11 loss or inhibition drives a rapid increase in 2-OG levels by impairing lipoylation of the 2-OG dehydrogenase complex (OGDHc)—the rate limiting step for mitochondrial 2-OG metabolism.
ABHD11 is one of several genes deleted in Williams–Beuren syndrome, a developmental disorder associated with haploinsufficiency of multiple genes.
The results of bioinformatic analysis demonstrated that ABHD11 and ABHD10 were downregulated, while most other ABHD family genes, such as Abhd 1, 3, 5, 6, and 7 were upregulated in OCT4-negative cells.
ABHD11 knockout disturbed GSK3β/β-Catenin and ERK signaling transduction; ABHD11 knockout led to the misexpression of key metabolic enzymes related to lipid synthesis, glycolysis, and amino acid metabolism.
The ABHD11 often as a prognostic marker of renal cancer.
Kidney - Transmembrane transport (mainly)
In yeast, the overexpression of ABHD11 or its yeast homolog causes a reduction in the levels of non-polar lipids.
1. plasma membrane, 2. endosome, 3. mitochondrion
This results suggested that the ABHD11 gene promote cancer cell proliferation, metastasis, and invasion, and inhibit cancer cell apoptosis.
Customer Reviews (4)
Write a reviewGreat work on ELISA with recommended dilution !
Excellent quality products!
We are satisfied with the WB results of ABHD11 product.
After-sales questions were answered in a timely manner. Good!
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